Upregulation of ATF3 inhibits expression of the pro-inflammatory cytokine IL-6 during Neisseria gonorrhoeae infection.
Upregulation of ATF3 inhibits expression of the pro-inflammatory cytokine IL-6 during Neisseria gonorrhoeae infection.
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DOI：
10.1111/cmi.12153
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发表时间：
2013-11
影响因子：
3.4
通讯作者：
So M
中科院分区：
文献类型：
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作者：
Calton CM;Wade LK;So M
Neisseria gonorrhoeae regulates the expression of epithelial cell genes, activates cytoprotective pathways in the infected cell and protects it from apoptosis. Many of these responses are enhanced by the Type IV pilus (Tfp). We tested the hypothesis that N. gonorrhoeae modulates the innate immune response by inducing expression of ATF3, a transcription factor that negatively regulates the expression of many cytokine genes. We further determined whether Tfp are involved in these events. We found that N. gonorrhoeae induces ATF3 expression in mucosal epithelial cells through activation of mitogen activated protein kinases. Maximal ATF3 expression requires Tfp retraction. Knocking down endogenous levels of ATF3 results in higher levels of IL-6 transcript. Our findings strongly suggest that ATF3 is involved in suppressing cytokine expression during gonococcal infection. We propose a model for the role of ATF3 in the context of N. gonorrhoeae infection.
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DOI：
10.1073/pnas.88.9.3720
发表时间：
1991-05-01
影响因子：
11.1
作者：
HAI, T;CURRAN, T
通讯作者：
CURRAN, T
DOI：
10.1084/jem.20072254
发表时间：
2008-09-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gilchrist M;Henderson WR Jr;Clark AE;Simmons RM;Ye X;Smith KD;Aderem A
通讯作者：
Aderem A
影响因子：
3.1
作者：
Fichorova, RN;Desai, PJ;Genco, CA
通讯作者：
Genco, CA
影响因子：
3.4
作者：
Criss AK;Katz BZ;Seifert HS
通讯作者：
Seifert HS
影响因子：
8
作者：
通讯作者：
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