Membrane contact sites and cytoskeleton-membrane interactions in autophagy.

Membrane contact sites and cytoskeleton-membrane interactions in autophagy.
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DOI:
10.1002/1873-3468.14414
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发表时间:
2022-09
期刊:
影响因子:
3.5
通讯作者:
Hussey PJ
Hussey PJ
中科院分区:
生物学3区
文献类型:
--
作者:
Duckney PJ;Wang P;Hussey PJ

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In Eukaryotes, organelle interactions occur at specialised contact sites between organelle membranes. Contact sites are regulated by specialised tethering proteins, which bring organelle membranes into close proximity, and facilitate functional crosstalk between compartments. While contact site proteins are well characterised in mammals and yeast, the regulators of plant contact site formation are only now beginning to emerge. Having unique subcellular structures, plants must also utilise unique mechanisms of organelle interaction to regulate plant‐specific functions. The recently characterised NETWORKED proteins are the first dedicated family of plant‐specific contact site proteins. Research into the NET proteins and their interacting partners continues to uncover plant‐specific mechanisms of organelle interaction and the importance of these organelle contacts to plant life. Moreover, it is becoming increasingly apparent that organelle interactions are fundamental to autophagy in plants. Here, we will present recent developments in our understanding of the mechanisms of plant organelle interactions, their functions, and emerging roles in autophagy. This review outlines the known mechanisms by which plants regulate interactions between organelles, their functions and importance to plant life. We discuss how ongoing research of the NETWORKED protein family and their interacting partners continues to uncover novel mechanisms of organelle interaction, as well as the emerging roles for plant membrane contact sites in the regulation of autophagy.
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