Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration.

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration.
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DOI:
10.1083/jcb.201808118
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发表时间:
2018-10-01
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Shadel GS
Shadel GS
中科院分区:
其他
文献类型:
--
作者:
Newman LE;Shadel GS

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Newman and Shadel preview new work from the Youle laboratory published in Nature indicating that mitophagy mitigates STING-induced inflammation. What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature. https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS–STING pathway that may contribute to Parkinson’s disease.
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