Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration.
Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration.
复制标题
DOI：
10.3389/fnins.2022.1003145
复制
发表时间：
2022
影响因子：
4.3
通讯作者：
Vaz, Sandra H. H.
中科院分区：
文献类型：
--
作者：
Costa, Goncalo;Ribeiro, Filipa F. F.;Sebastiao, Ana M. M.;Muir, Elizabeth M. M.;Vaz, Sandra H. H.
关键词：
中枢神经系统(CNS)中的神经元再生是一个重要的研究领域，与包括神经退行性疾病在内的所有类型的神经元损伤有关。胶质瘢痕是星形胶质细胞对中枢神经系统损伤反应的结果。它由许多组件组成，创造了一个复杂的环境，星形胶质细胞在其中扮演着各种关键角色。胶质瘢痕是异质性的，其成分取决于损伤的类型和位置。在中枢神经系统损伤的不同情况下观察到的胶质瘢痕的异质性以及由此对轴突再生的影响尚未进行深入的综述。这方面的知识差距将在本综述中解决，也将集中在我们目前对中枢轴突再生及其分子机制的理解上。我们讨论了中枢神经系统再生的多因素背景，并回顾了以前被认为在中枢再生中唯一起抑制作用的成分：星形胶质细胞和p75NTR的新发现的作用，并讨论了它们对决定治疗干预的潜力和相关性。文章最后对中枢神经系统轴突再生的新治疗靶点进行了全面的综述，并讨论了几种脑部疾病和损伤的治疗干预的新方法。
Neuronal regeneration in the central nervous system (CNS) is an important field of research with relevance to all types of neuronal injuries, including neurodegenerative diseases. The glial scar is a result of the astrocyte response to CNS injury. It is made up of many components creating a complex environment in which astrocytes play various key roles. The glial scar is heterogeneous, diverse and its composition depends upon the injury type and location. The heterogeneity of the glial scar observed in different situations of CNS damage and the consequent implications for axon regeneration have not been reviewed in depth. The gap in this knowledge will be addressed in this review which will also focus on our current understanding of central axonal regeneration and the molecular mechanisms involved. The multifactorial context of CNS regeneration is discussed, and we review newly identified roles for components previously thought to solely play an inhibitory role in central regeneration: astrocytes and p75NTR and discuss their potential and relevance for deciding therapeutic interventions. The article ends with a comprehensive review of promising new therapeutic targets identified for axonal regeneration in CNS and a discussion of novel ways of looking at therapeutic interventions for several brain diseases and injuries.
登录
查看更多内容
影响因子：
3.5
作者：
Perdigoto, Ana Luisa;Chaudhry, Nagarathnamma;Barnes, Gregory N.;Filbin, Marie T.;Carter, Bruce D.
通讯作者：
Carter, Bruce D.
影响因子：
5.3
作者：
Ben Haim L;Carrillo-de Sauvage MA;Ceyzériat K;Escartin C
通讯作者：
Escartin C
影响因子：
--
作者：
Bylicky MA;Mueller GP;Day RM
通讯作者：
Day RM
DOI：
10.1093/brain/awy158
发表时间：
2018-08-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Burnside ER;De Winter F;Didangelos A;James ND;Andreica EC;Layard-Horsfall H;Muir EM;Verhaagen J;Bradbury EJ
通讯作者：
Bradbury EJ
影响因子：
5.3
作者：
Andrews, Melissa R.;Czvitkovich, Stefan;Fawcett, James W.
通讯作者：
Fawcett, James W.