Insulin Through the Ages : Phylogeny of a Growth Promoting and Metabolic Regulatory Hormone
Insulin Through the Ages : Phylogeny of a Growth Promoting and Metabolic Regulatory Hormone
复制标题
各个时代的胰岛素：促生长和代谢调节激素的系统发育
DOI：
10.1093/icb/40.2.213
复制
发表时间：
2000
期刊：
影响因子：
56.9
通讯作者：
D. Steiner
中科院分区：
文献类型：
--
作者：
S. J. Chan;D. Steiner
剧情简介。胰岛素于1922年被发现是人类代谢紊乱（糖尿病）的致病因素，但人们很早就认识到这种激素具有广泛的系统发育分布。到20世纪70年代中期，胰岛素已经从包括阿格纳塔动物在内的所有脊椎动物中分离出来并进行了测序。研究还发现，脊椎动物的胰岛素基因家族包括两种密切相关的激素，即胰岛素样生长因子(IGF)-I和-II。最近，重组DNA技术的应用已经在无脊椎动物（包括昆虫、软体动物和线虫）中鉴定出胰岛素样肽基因，这些发现清楚地表明胰岛素是一种进化上古老的激素，存在于所有后生动物中。在这里，我们简要回顾了胰岛素/ IGF基因家族在脊椎动物和无脊椎动物中的结构和功能。虽然这些研究仍在进行中，但似乎在无脊椎动物中，胰岛素样肽主要作为促有丝分裂生长因子发挥作用，促进组织生长和发育。然而，在脊椎动物中，有丝分裂生长功能已被IGF-I和-II所包含，而胰岛素已获得主要作为代谢调节激素的功能。这种发育所必需的基因复制和分化事件可能发生在脊椎动物进化的早期，从以现存文文鱼为代表的原脊索动物到以现存的七鳃鳗和盲鳗为代表的原始无颌脊椎动物。
SYNOPSIS. Insulin was discovered in 1922 as the causative factor for a human metabolic disorder (diabetes mellitus), but it was recognized early that the hormone had a broad phylogenetic distribution. By the mid 1970s, insulin had been isolated and sequenced from all classes of vertebrates, including Agnatha. Also it was discovered that the insulin gene family in vertebrates included two closely related hormones named insulin-like growth factor (IGF)-I and -II. More recently, the application of recombinant DNA techniques have identified insulin-like peptide genes in invertebrates, including insects, molluscs and nematode and these findings clearly establish that insulin is an evolutionarily ancient hormone which is present in all metazoa. Here we briefly review the structure and function of the insulin/ IGF gene family in vertebrates and invertebrates. Although these studies are ongoing, it appears that in invertebrates the insulin-like peptides function predominately as mitogenic growth factors that act to promote tissue growth and development. However, in vertebrates the mitogenic growth function has been subsumed by IGF-I and -II while insulin has acquired the function of being primarily a metabolic regulatory hormone. The gene duplication and divergence events necessary for this development probably occurred early during vertebrate evolution in the transition from protochordates, represented by extant amphioxus, to primitive jawless vertebrates, represented by extant lamprey and hagfish.
登录
查看更多内容
秀丽隐杆线虫胰岛素样基因家族新成员的克隆和发育调控。
影响因子：
3.1
作者：
Gregoire,FM;Chomiki,N;Kachinskas,D;Warden,CH
通讯作者：
Warden,CH
DOI：
10.1073/pnas.87.23.9319
发表时间：
1990-12-01
影响因子：
11.1
作者：
CHAN, SJ;CAO, QP;STEINER, DF
通讯作者：
STEINER, DF
影响因子：
--
作者：
Mohammad Pashmforoush;S. J. Chan;D. F. Steiner
通讯作者：
Mohammad Pashmforoush;S. J. Chan;D. F. Steiner
影响因子：
56.9
作者：
Kimura, KD;Tissenbaum, HA;Ruvkun, G
通讯作者：
Ruvkun, G