The evolution of genomic imprinting: theories, predictions and empirical tests.
The evolution of genomic imprinting: theories, predictions and empirical tests.
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DOI：
10.1038/hdy.2014.29
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发表时间：
2014-08
期刊：
影响因子：
3.8
通讯作者：
Wolf, J. B.
中科院分区：
文献类型：
--
作者：
Patten, M. M.;Ross, L.;Curley, J. P.;Queller, D. C.;Bonduriansky, R.;Wolf, J. B.
基因组印记的表观遗传现象激发了许多关于其进化起源和基因组分布的理论的发展。在这篇综述中，我们研究了三个理论，最经得起理论和实证审查。这些理论包括：黑格及其同事的亲属关系理论；戴和邦杜良斯基的性对抗理论；以及Wolf和Hager的母子共同适应理论。这些理论对印记的适应性意义有着根本不同的观点。亲属理论认为印记是一种改变基因剂量的机制，印记的进化是由于基因剂量对母系和父系亲属适合度的不同影响。性别对抗和母-子共适应理论认为基因组印记是一种改变个体与其双亲相似性的机制，印记的进化增加了基因座上两个等位基因表达更合适的可能性。为了进一步刺激对这一主题的实证研究，我们仔细地详细说明了所有三种理论的逻辑和假设，澄清了每种理论的具体预测，并提出了区分这些替代理论的测试，以解释为什么特定基因会被印记。
The epigenetic phenomenon of genomic imprinting has motivated the development of numerous theories for its evolutionary origins and genomic distribution. In this review, we examine the three theories that have best withstood theoretical and empirical scrutiny. These are: Haig and colleagues' kinship theory; Day and Bonduriansky's sexual antagonism theory; and Wolf and Hager's maternal–offspring coadaptation theory. These theories have fundamentally different perspectives on the adaptive significance of imprinting. The kinship theory views imprinting as a mechanism to change gene dosage, with imprinting evolving because of the differential effect that gene dosage has on the fitness of matrilineal and patrilineal relatives. The sexual antagonism and maternal–offspring coadaptation theories view genomic imprinting as a mechanism to modify the resemblance of an individual to its two parents, with imprinting evolving to increase the probability of expressing the fitter of the two alleles at a locus. In an effort to stimulate further empirical work on the topic, we carefully detail the logic and assumptions of all three theories, clarify the specific predictions of each and suggest tests to discriminate between these alternative theories for why particular genes are imprinted.
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影响因子：
16.8
作者：
Drewell, Robert A.;Lo, Nathan;Oldroyd, Benjamin P.
通讯作者：
Oldroyd, Benjamin P.
DOI：
10.1111/j.1749-6632.2000.tb06621.x
发表时间：
2000-01-01
期刊：
EVOLUTIONARY PERSPECTIVES ON HUMAN REPRODUCTIVE BEHAVIOR
影响因子：
--
作者：
Haig, D
通讯作者：
Haig, D
DOI：
10.1073/pnas.1100921108
发表时间：
2011-06-28
影响因子：
11.1
作者：
Frank, Steven A.;Crespi, Bernard J.
通讯作者：
Crespi, Bernard J.
DOI：
10.1073/pnas.96.9.5083
发表时间：
1999-04-27
影响因子：
11.1
作者：
Holland, B;Rice, WR
通讯作者：
Rice, WR
影响因子：
2.1
作者：
Haig, D
通讯作者：
Haig, D