Multiscale analysis of morphology and mechanics in tail tendon from the ZDSD rat model of type 2 diabetes.
Multiscale analysis of morphology and mechanics in tail tendon from the ZDSD rat model of type 2 diabetes.
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DOI：
10.1016/j.jbiomech.2013.11.045
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发表时间：
2014-02-07
影响因子：
2.4
通讯作者：
Wallace, Joseph M.
中科院分区：
文献类型：
--
作者：
Gonzalez, Armando Diaz;Gallant, Maxime A.;Burr, David B.;Wallace, Joseph M.
2 型糖尿病 (T2D) 影响多个器官系统，包括循环系统、肾脏系统、神经系统和肌肉骨骼系统。在胶原蛋白组织中，可能导致 T2D 有害机械影响的一种机制是晚期糖基化终产物 (AGE) 的形成，导致胶原蛋白硬度增加和韧性下降，从而导致脆性组织行为。本研究的目的是研究正常大鼠和糖尿病大鼠在两种不同长度尺度上的肌腱机械特性，检验纤维水平上硬度和强度增加以及韧性降低与纳米级形态和力学变化相关的假设。与对照大鼠 (CD) 相比，雌性 Zucker 糖尿病 Sprague-Dawley (ZDSD) 大鼠的单个肌束在肌束水平机械性能方面没有差异，但材料水平强度和刚度有所增加。在纳米尺度上，糖尿病 ZDSD 原纤维中的胶原原纤维 D 间距向更高的间距值转变。纳米级模量值的分布也转向更高的值。 ZDSD 尾部的全纤维测试的材料级强度和刚度有所提高。纳米级和微米级特性之间的相关性表明两个长度尺度之间存在直接的正相关关系，最显着的是纳米级和微米级模量之间的关系。这些发现表明，糖尿病引起的材料强度和模量的变化是由纳米尺度的变化驱动的。
Type 2 diabetes (T2D) impacts multiple organ systems including the circulatory, renal, nervous and musculoskeletal systems. In collagen-based tissues, one mechanism that may be responsible for detrimental mechanical impacts of T2D is the formation of advanced glycation end products (AGEs) leading to increased collagen stiffness and decreased toughness, resulting in brittle tissue behavior. The purpose of this study was to investigate tendon mechanical properties from normal and diabetic rats at two distinct length scales, testing the hypothesis that increased stiffness and strength and decreased toughness at the fiber level would be associated with alterations in nanoscale morphology and mechanics. Individual fascicles from female Zucker diabetic Sprague-Dawley (ZDSD) rats had no differences in fascicle-level mechanical properties but had increased material-level strength and stiffness versus control rats (CD). At the nanoscale, collagen fibril D-spacing was shifted towards higher spacing values in diabetic ZDSD fibrils. The distribution of nanoscale modulus values was also shifted to higher values. Material-level strength and stiffness from whole fiber tests were increased in ZDSD tails. Correlations between nanoscale and microscale properties indicate a direct positive relationship between the two length scales, most notably in the relationship between nanoscale and microscale modulus. These findings indicate that diabetes-induced changes in material strength and modulus were driven by alterations at the nanoscale.
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影响因子：
9.7
作者：
Screen, Hazel R. C.;Chhaya, Vivek H.;Shelton, Julia C.
通讯作者：
Shelton, Julia C.
DOI：
10.1152/ajpendo.90937.2008
发表时间：
2009-04-01
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
3
作者：
Kemp, Arika D.;Harding, Chad C.;Cabral, Wayne A.;Marini, Joan C.;Wallace, Joseph M.
通讯作者：
Wallace, Joseph M.
影响因子：
2.9
作者：
KASTELIC, J;GALESKI, A;BAER, E
通讯作者：
BAER, E
影响因子：
4.1
作者：
Hammond, Max A.;Gallant, Maxime A.;Burr, David B.;Wallace, Joseph M.
通讯作者：
Wallace, Joseph M.