Partial Tendon Injury at the Tendon-to-Bone Enthesis Activates Skeletal Stem Cells.
Partial Tendon Injury at the Tendon-to-Bone Enthesis Activates Skeletal Stem Cells.
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在肌腱到骨的部分肌腱损伤激活骨骼干细胞。
DOI：
10.1093/stcltm/szac027
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发表时间：
2022-07-20
影响因子：
6
通讯作者：
Michael Longaker
中科院分区：
文献类型：
--
作者：
Titan, Ashley L.;Davitt, Michael;Foster, Deshka;Salhotra, Ankit;Menon, Siddharth;Chen, Kellen;Fahy, Evan;Lopez, Michael;Jones, R. Ellen;Baiu, Ioana;Burcham, Austin;Januszyk, Michael;Gurtner, Geoffrey;Fox, Paige;Chan, Charles;Quarto, Natalina;Michael Longaker
The tendon enthesis plays a critical role in facilitating movement and reducing stress within joints. Partial enthesis injuries heal in a mechanically inferior manner and never achieve healthy tissue function. The cells responsible for tendon-to-bone healing remain incompletely characterized and their origin is unknown. Here, we evaluated the putative role of mouse skeletal stem cells (mSSCs) in the enthesis after partial-injury. We found that mSSCs were present at elevated levels within the enthesis following injury and that these cells downregulated TGFβ signaling pathway elements at both the RNA and protein levels. Exogenous application of TGFβ post-injury led to a reduced mSSC response and impaired healing, whereas treatment with a TGFβ inhibitor (SB43154) resulted in a more robust mSSC response. Collectively, these data suggest that mSSCs may augment tendon-to-bone healing by dampening the effects of TGFβ signaling within the mSSC niche.
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影响因子：
14.9
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
通讯作者：
Ma'ayan A
影响因子：
2.8
作者：
Galatz, LM;Sandell, LJ;Thomopoulos, S
通讯作者：
Thomopoulos, S
影响因子：
2.4
作者：
Benjamin, M;Toumi, H;Milz, S
通讯作者：
Milz, S
影响因子：
2.4
作者：
Beason, David P.;Kuntz, Andrew F.;Soslowsky, Louis J.
通讯作者：
Soslowsky, Louis J.
影响因子：
7.7
作者：
Kaji, Deepak A.;Howell, Kristen L.;Huang, Alice H.
通讯作者：
Huang, Alice H.