Anxiolytic and antidepressant potential of extracts of Duchesnea Indica in animal models
Anxiolytic and antidepressant potential of extracts of Duchesnea Indica in animal models
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Duchesnea Indica 提取物在动物模型中的抗焦虑和抗抑郁潜力
DOI：
10.62368/pn.v1i01.12
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Haroon Khan
中科院分区：
文献类型：
--
作者：
Mohibullah;Abdul Saboor Pirzada;M. Aschner;Haroon Khan
本研究旨在探讨蛇莓的抗焦虑和抗抑郁活性。在白化病小鼠（20-30 g，6-8周）中测试植物的甲醇提取物和正己烷级分。在不同剂量下测定每种提取物的安全性特征。采用高架十字迷宫和光暗模型测定了不同浓度的甲醇和正己烷提取物对植物的解毒作用。不同剂量的悬尾法和强迫游泳法对小鼠的抗抑郁作用有辅助作用。结果表明，D.结论：薏苡仁具有显著的抗焦虑、抗抑郁作用（P < 0.05）。100 mg和200 mg的甲醇提取物显著增加了亮区和暗区模型的时间，增加了高架十字迷宫模型的开放臂时间。与对照组相比，5 mg和10 mg/kg剂量的正己烷提取物显著增加了亮区和暗区模型的时间，增加了高架十字迷宫模型的开放臂时间。D. Indica在100 mg/kg和200 mg/kg剂量下显著缩短尾悬吊和强迫游泳模型的不动时间。正己烷提取物100 mg/kg和200 mg/kg剂量组与对照组相比，能明显缩短强迫游泳和悬尾模型小鼠的不动时间，具有抗应激作用。从以上观察，可以假设该植物具有显著的抗焦虑和抗抑郁潜力。然而，还需要进一步的研究来确定潜在的确切机制和临床用途。
THIS study was designed to investigate the anxiolytic and antidepressant activity of Duchesnea Indica. The methanolic extract and n-hexane fraction of plant were tested in albino mice (20–30 g of 6–8 week). Safety profile of each extract was determined at different doses. Anxiolytic effect of plant was determined by Elevated Plus Maze and Light and Dark Model at different doses of methanolic and n-hexane extract. Antidepressant activities were assisted by Tail Suspension and Forced Swim Model at different doses. Result illustrated that D. Indica had a significant (P < 0.05) potential of reducing anxiety and depression. The methanolic extract at 100 mg and 200 mg significantly increased the time spend in light region of light and dark model and more time spent in open arm of Elevated Plus Maze model. n-hexane extract at dose of 5 mg and 10 mg/kg significantly increases the time spend in light region of Light and dark model and more time spend in open arm of Elevated Plus Maze model as compare to Control group. Methanolic extract of D. Indica significantly reduced the time of immobility in Tail Suspension and Force Swim Model at Dose of 100 mg and 200mg/kg. n-hexane extract also exhibit anti-depressant effect by reducing the time of immobility in Force swim and tail suspension Model at 100 mg and 200mg/kg dose as compare to control group. From the above observations, it could be assumed that the plant has marked anxiolytic and antidepressant potential. However further additional studies will be necessary to determine the underlying exact mechanism and clinical uses.
有犯罪风险的青春期前男孩的记忆和焦虑。
DOI：
10.1097/00004583-199908000-00019
发表时间：
1999
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry.
影响因子：
--
作者：
Pine,DS;Wasserman,GA;Workman,SB
通讯作者：
Workman,SB
影响因子：
1.2
作者：
Can, Adem;Dao, David T.;Gould, Todd D.
通讯作者：
Gould, Todd D.