Reproducibility of automated calculation technique for diffusion tensor image analysis along the perivascular space
Reproducibility of automated calculation technique for diffusion tensor image analysis along the perivascular space
复制标题
沿血管周围空间的扩散张量图像分析的自动计算技术的再现性
DOI：
10.1007/s11604-023-01415-0
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发表时间：
2023
影响因子：
2.1
通讯作者：
Aoki Shigeki
中科院分区：
文献类型：
--
作者：
Saito Yuya;Kamagata Koji;Andica Christina;Uchida Wataru;Takabayashi Kaito;Yoshida Seina;Nakaya Moto;Tanaka Yuya;Kamiyo Satoru;Sato Kanako;Nishizawa Mitsuo;Akashi Toshiaki;Shimoji Keigo;Wada Akihiko;Aoki Shigeki
目的沿血管周围间隙弥散张量图像分析（DTI-ALPS）方法在评价脑淋巴功能或间质流体动力学方面受到重视。然而，据我所知，还没有对这些自动方法对ALPS指数值的再现性进行过研究。因此，本研究采用两种主要的自动计算技术，在同一受试者同一天的扫描和重新扫描中，基于DTI-ALPS评估ALPS指数的可重复性。材料与方法本研究共纳入23例受试者，其中阿尔茨海默病2例，轻度认知障碍15例，认知正常6例。获取扩散磁共振图像的扫描和重扫描数据，并在FSL软件计算的模板分数各向异性图上自动索引ALPS指数（ALPS index）和保持张量矢量方向信息的ALPS指数（vALPS index）。在扫描和重新扫描的再现性方面比较这些ALPS指数。结果扫描与重新扫描的ALPS指数的绝对差值比vALPS指数的相对差值大约0.6%。方法间左右两种ALPS指数的Cohen’s分别为0.121和0.159。结论基于DTI-ALPS维持张量向量方位信息的vALPS指数比ALPS指数具有更高的再现性。这一结果鼓励对ALPS指数进行多地点大样本量的研究，并有助于发现ALPS指数的细微病理变化。
PurposeThe method of diffusion tensor image analysis along the perivascular space (DTI-ALPS) was gathering attention to evaluate the brain’s glymphatic function or interstitial fluid dynamics. However, to the best knowledge, no study was conducted on the reproducibility of these automated methods for ALPS index values. Therefore, the current study evaluated the ALPS index reproducibility based on DTI-ALPS using two major automated calculation techniques in scan and rescan of the same subject on the same day.Materials and methodsThis study included 23 participants, including 2 with Alzheimer’s disease, 15 with mild cognitive impairment, and 6 with cognitive normals. Scan and rescan data of diffusion magnetic resonance images were obtained, as well as automatically index for ALPS (ALPS index) and ALPS index maintaining tensor vector orientation information (vALPS index) with region of interest on the template fractional anisotropy map calculated by FSL software.These ALPS indices were compared in terms of scan and rescan reproducibility.ResultsThe absolute difference in ALPS-index values between scan and rescan was larger in the ALPS index than in the vALPS index by approximately 0.6% as the relative difference. Cohen’sdfor the left and right ALPS indices between methods were 0.121 and 0.159, respectively.ConclusionThe vALPS index based on DTI-ALPS maintaining tensor vector orientation information has higher reproducibility than the ALPS index. This result encourages a multisite study on the ALPS index with a large sample size and helps detect a subtle pathological change in the ALPS index.
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影响因子：
4.8
作者：
Zhang Y;Zhang R;Ye Y;Wang S;Jiaerken Y;Hong H;Li K;Zeng Q;Luo X;Xu X;Yu X;Wu X;Yu W;Zhang M;Huang P
通讯作者：
Huang P
影响因子：
2.1
作者：
Taoka T;Ito R;Nakamichi R;Kamagata K;Sakai M;Kawai H;Nakane T;Abe T;Ichikawa K;Kikuta J;Aoki S;Naganawa S
通讯作者：
Naganawa S
脑膜瘤的瘤周脑水肿体积与肿瘤各向异性分数相关，但与表观扩散系数或脑血容量无关
影响因子：
2.8
作者：
C. Toh;M. Castillo
通讯作者：
M. Castillo
影响因子：
2.8
作者：
H. Siebner;H. G. von Einsiedel;B. Conrad
通讯作者：
B. Conrad
影响因子：
3.4
作者：
Nguchu BA;Zhao J;Wang Y;de Dieu Uwisengeyimana J;Wang X;Qiu B;Li H
通讯作者：
Li H