Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study.
Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study.
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DOI：
10.1007/s11604-021-01187-5
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发表时间：
2022-03
影响因子：
2.1
通讯作者：
Naganawa S
中科院分区：
文献类型：
--
作者：
Taoka T;Ito R;Nakamichi R;Kamagata K;Sakai M;Kawai H;Nakane T;Abe T;Ichikawa K;Kikuta J;Aoki S;Naganawa S
应用沿着血管周隙扩散张量图像分析（DTI-ALPS）方法评价脑胶质淋巴功能或间质流体动力学。本研究旨在评价DTI-ALPS方法的重现性以及成像方法和数据评价中的修改效果。7名健康志愿者入组本研究。使用固定的成像序列和改良的成像方法（包括感兴趣区域（ROI）的放置、成像平面、头部位置、平均值、运动证明梯度的数量、回波时间（TE）和不同的扫描仪），对该重测研究进行图像采集。针对上述条件的变化，评价了ALP指数值。通过固定成像序列进行的该测试-再测试研究显示出对于ALPS指数值的非常高的再现性（组内系数= 0.828）。双侧ROI位置显示出较高的可重复性。平均值的数量和扫描仪的差异不影响ALPS指数值。然而，成像平面和头部位置的修改损害了再现性，并且运动证明梯度的数量影响了ALPS指数值。12轴DTI和3轴DWI的ALPS指数值具有良好的相关性（r = 0.86）。此外，较短的TE导致较大的ALPS指数值。即使使用不同的扫描仪，ALPS指数在固定成像方法下也是稳健的。ALPS指数受成像平面、运动证明梯度轴的数量和成像序列中的TE的影响。在规划ALPS方法研究中应统一这些因素。还提出了使用三个轴的运动证明梯度开发三轴DWI-ALPS方法的可能性。
The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was developed to evaluate the brain’s glymphatic function or interstitial fluid dynamics. This study aimed to evaluate the reproducibility of the DTI-ALPS method and the effect of modifications in the imaging method and data evaluation. Seven healthy volunteers were enrolled in this study. Image acquisition was performed for this test–retest study using a fixed imaging sequence and modified imaging methods which included the placement of region of interest (ROI), imaging plane, head position, averaging, number of motion-proving gradients, echo time (TE), and a different scanner. The ALPS-index values were evaluated for the change of conditions listed above. This test–retest study by a fixed imaging sequence showed very high reproducibility (intraclass coefficient = 0.828) for the ALPS-index value. The bilateral ROI placement showed higher reproducibility. The number of averaging and the difference of the scanner did not influence the ALPS-index values. However, modification of the imaging plane and head position impaired reproducibility, and the number of motion-proving gradients affected the ALPS-index value. The ALPS-index values from 12-axis DTI and 3-axis diffusion-weighted image (DWI) showed good correlation (r = 0.86). Also, a shorter TE resulted in a larger value of the ALPS-index. ALPS index was robust under the fixed imaging method even when different scanners were used. ALPS index was influenced by the imaging plane, the number of motion-proving gradient axes, and TE in the imaging sequence. These factors should be uniformed in the planning ALPS method studies. The possibility to develop a 3-axis DWI-ALPS method using three axes of the motion-proving gradient was also suggested.
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DOI：
10.2463/mrms.mp.2020-0062
发表时间：
2021-09-01
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Naganawa S;Ito R;Nakamichi R;Kawamura M;Kawai H;Taoka T;Yoshida T;Sone M
通讯作者：
Sone M
影响因子：
--
作者：
Chen HL;Chen PC;Lu CH;Tsai NW;Yu CC;Chou KH;Lai YR;Taoka T;Lin WC
通讯作者：
Lin WC
DOI：
10.2463/mrms.mp.2020-0030
发表时间：
2021-03-01
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Naganawa S;Ito R;Kato Y;Kawai H;Taoka T;Yoshida T;Maruyama K;Murata K;Körzdörfer G;Pfeuffer J;Nittka M;Sone M
通讯作者：
Sone M
影响因子：
2.8
作者：
Fujiwara, Shunrou;Sasaki, Makoto;Ogawa, Akira
通讯作者：
Ogawa, Akira
影响因子：
3.3
作者：
Lin, Mu;He, Hongjian;Zhong, Jianhui
通讯作者：
Zhong, Jianhui