Selenoprotein S: A versatile disordered protein.
Selenoprotein S: A versatile disordered protein.
复制标题
DOI：
10.1016/j.abb.2022.109427
复制
发表时间：
2022-11-30
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
硒蛋白S是一种小分子膜蛋白，与炎症过程、细胞应激反应、蛋白质质量控制和信号转导等多种细胞功能有关。它主要是因为它在内质网相关降解(ERAD)途径中的作用而闻名，该途径调控着将错误折叠的蛋白质或错误组装的蛋白质复合体从内质网提取到细胞质中，由蛋白酶体降解。然而，Selenos在信号传递中的其他细胞作用也同样重要，包括控制转录因子和细胞因子水平。因此，硒的基因多态与糖尿病、血脂异常和心血管疾病的风险增加相关，而在一些癌症中，高表达水平与不良预后相关。它对细胞因子分泌的抑制作用也被病毒所利用。然而，由于Seenos结合了多种蛋白质复合体，其在各种细胞途径和疾病中的具体作用一直难以确定。因此，硒的确切细胞功能及其相互联系直到最近才开始出现。该综述旨在总结最新的洞察力的结构，相互作用组，和细胞的作用。
Selenoprotein S (selenos) is a small, intrinsically disordered membrane protein that is associated with various cellular functions, such as inflammatory processes, cellular stress response, protein quality control, and signaling pathways. It is primarily known for its contribution to the ER-associated degradation (ERAD) pathway, which governs the extraction of misfolded proteins or misassembled protein complexes from the ER to the cytosol for degradation by the proteasome. However, selenos’s other cellular roles in signaling are equally vital, including the control of transcription factors and cytokine levels. Consequently, genetic polymorphisms of selenos are associated with increased risk for diabetes, dyslipidemia, and cardiovascular diseases, while high expression levels correlate with poor prognosis in several cancers. Its inhibitory role in cytokine secretion is also exploited by viruses. Since selenos binds multiple protein complexes, however, its specific contributions to various cellular pathways and diseases have been difficult to establish. Thus, the precise cellular functions of selenos and their interconnectivity have only recently begun to emerge. This review aims to summarize recent insights into the structure, interactome, and cellular roles of selenos.
登录
查看更多内容
通过破坏的顺序：与ER相关的蛋白质降解如何有助于细胞器稳态。
DOI：
10.15252/embj.2021109845
发表时间：
2022-03-15
期刊：
The EMBO journal
影响因子：
--
作者：
Christianson JC;Carvalho P
通讯作者：
Carvalho P
影响因子：
5.2
作者：
Costantini S;Polo A;Capone F;Accardo M;Sorice A;Lombardi R;Bagnara P;Zito Marino F;Amato M;Orditura M;Fratelli M;Ciliberto G;Budillon A
通讯作者：
Budillon A
DOI：
10.1152/ajpregu.00321.2019
发表时间：
2020-05-01
影响因子：
2.8
作者：
Addinsall, Alex Bernard;Wright, Craig Robert;Stupka, Nicole
通讯作者：
Stupka, Nicole
丙烯醛靶标的定量和位点特异性化学蛋白质组学分析
影响因子：
4.1
作者：
Chen, Ying;Liu, Yuan;Wang, Chu
通讯作者：
Wang, Chu
影响因子：
3.7
作者：
Bubenik JL;Miniard AC;Driscoll DM
通讯作者：
Driscoll DM