Impact of the Mk VI SkinSuit on skin microbiota of terrestrial volunteers and an International Space Station-bound astronaut.
Impact of the Mk VI SkinSuit on skin microbiota of terrestrial volunteers and an International Space Station-bound astronaut.
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DOI：
10.1038/s41526-017-0029-5
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发表时间：
2017
期刊：
影响因子：
5.1
通讯作者：
Taylor PW
中科院分区：
文献类型：
--
作者：
Stabler RA;Rosado H;Doyle R;Negus D;Carvil PA;Kristjánsson JG;Green DA;Franco-Cendejas R;Davies C;Mogensen A;Scott J;Taylor PW
由于缺乏重力负荷，微重力诱导生理失调，导致骨密度损失，下肢骨骼和体位肌萎缩，脊柱延长。SkinSuit是一种轻量级的压缩服，设计用于在太空飞行中提供从头到脚（轴向）载荷，以抵消脊柱伸长。由于合成服装可能会对皮肤微生物群产生负面影响，我们使用16S核糖体RNA （rRNA）基因扩增子程序来确定5名接受SkinSuit评估的健康男性志愿者皮脂腺和湿润身体部位的细菌皮肤群落。每个志愿者在每个皮肤部位都展示了不同的、不同的细菌种群。穿着gym kit或SkinSuit进行短时间（8 h）的干燥超浮力漂浮，可引起属水平皮肤微生物群组成的变化，但对门水平的群落结构或细菌种群的丰富度和多样性影响很小或没有影响。我们还确定了宇航员在飞行前训练、在国际空间站8天访问期间（包括两次6-7小时的SkinSuit穿着）和返回后1个月的皮肤微生物群的组成。五个身体部位细菌皮肤群落组成的变化与地理位置的变化密切相关。一个明显的国际空间站细菌微生物群特征被发现，在返回时与飞行前的特征相反。没有发现微生物组复杂性或多样性的变化，几乎没有证据表明潜在致病菌定殖；我们的结论是，短时间的SkinSuit穿着会引起皮肤微生物群组成的变化，但这些变化不太可能损害健康的皮肤微生物群。一件对皮肤施加类似重力的压力的压缩服会改变皮肤微生物的组成，但不会以危险的方式改变。由英国伦敦大学学院的彼得·泰勒领导的一个研究小组，对五名地球志愿者在穿着Mk VI紧身衣前后干燥和湿润的身体部位的皮肤细菌群落进行了描述。Mk VI紧身衣创造了一个模拟重力作用的压力加载系统。皮肤套装8 h在属水平上改变了皮肤微生物群，但对群落结构几乎没有影响。研究人员发现，在国际空间站上穿着这种衣服的一名宇航员身上发生了更大的变化。然而，当宇航员返回地球时，微生物的组成又恢复到了飞行前的样子。研究结果表明，短期穿着SkinSuit不太可能损害皮肤的细菌健康。
Microgravity induces physiological deconditioning due to the absence of gravity loading, resulting in bone mineral density loss, atrophy of lower limb skeletal and postural muscles, and lengthening of the spine. SkinSuit is a lightweight compression suit designed to provide head-to-foot (axial) loading to counteract spinal elongation during spaceflight. As synthetic garments may impact negatively on the skin microbiome, we used 16S ribosomal RNA (rRNA) gene amplicon procedures to define bacterial skin communities at sebaceous and moist body sites of five healthy male volunteers undergoing SkinSuit evaluation. Each volunteer displayed a diverse, distinct bacterial population at each skin site. Short (8 h) periods of dry hyper-buoyancy flotation wearing either gym kit or SkinSuit elicited changes in the composition of the skin microbiota at the genus level but had little or no impact on community structure at the phylum level or the richness and diversity of the bacterial population. We also determined the composition of the skin microbiota of an astronaut during pre-flight training, during an 8-day visit to the International Space Station involving two 6–7 h periods of SkinSuit wear, and for 1 month after return. Changes in composition of bacterial skin communities at five body sites were strongly linked to changes in geographical location. A distinct ISS bacterial microbiota signature was found which reversed to a pre-flight profile on return. No changes in microbiome complexity or diversity were noted, with little evidence for colonisation by potentially pathogenic bacteria; we conclude that short periods of SkinSuit wear induce changes to the composition of the skin microbiota but these are unlikely to compromise the healthy skin microbiome. A compression garment that applies gravity-like pressure to the skin alters the composition of skin microbes, but not in a dangerous manner. A team led by Peter Taylor from University College London, UK, characterised the bacterial skin communities at dry and moist body sites of five Earth-bound volunteers before and after wearing the Mk VI SkinSuit, which creates a pressure loading system that simulates gravity’s effects. 8 h in the SkinSuit changed the skin microbiota at the genus level but had little to no impact in community structure. The researchers observed more dramatic changes in one astronaut who wore the garment on the International Space Station. However, the microbial makeup reverted back to pre-flight profiles upon the astronaut’s return to Earth. The findings suggest that short-term SkinSuit wear is unlikely to compromise bacterial skin health.
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影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
影响因子：
3
作者：
Fahlen, Annika;Engstrand, Lars;Fry, Lionel
通讯作者：
Fry, Lionel
影响因子：
3.5
作者：
Kozlovsaya, IB;Grigoriev, AI;Stepantzov, VI
通讯作者：
Stepantzov, VI
DOI：
10.1073/pnas.1000080107
发表时间：
2011-03-15
影响因子：
11.1
作者：
Caporaso, J. Gregory;Lauber, Christian L.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
1.7
作者：
Campoccia, Davide;Montanaro, Lucio;Arciola, Carla Renata
通讯作者：
Arciola, Carla Renata