Association of KIR Genes and MHC Class I Ligands with Atopic Dermatitis.
Association of KIR Genes and MHC Class I Ligands with Atopic Dermatitis.
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DOI：
10.4049/jimmunol.2100379
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发表时间：
2021-09-15
期刊：
影响因子：
--
通讯作者：
Phillips EJ
中科院分区：
文献类型：
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作者：
Margolis DJ;Mitra N;Hoffstad OJ;Kim BS;Monos DS;Phillips EJ
特应性皮炎（AD）是一种与免疫失调有关的慢性疾病。自然杀伤（NK）细胞功能以前与AD相关。NK细胞利用杀伤细胞免疫球蛋白样受体（KIR）与多态性HLA I类配体变体直接相互作用。本研究的目的是通过评估KIR基因存在的变化以及KIR基因与适当的HLA I类KIR特异性配体的相互作用来确定NK细胞功能与AD之间的潜在关联。使用特应性皮炎遗传学病例对照研究中的人类DNA对HLA I类KIR特异性配体和KIR基因的存在进行基因分型。在整个队列中，注意到KIR 2DL 5（1.51（1.13，2.01））、KIR 2DS 5（1.72（1.26，2.34））和KIR 2DS 1（1.41（1.04，1.91））的AD风险增加。携带KIR 2DS 5或KIR 2DS 1和HLA-C*C2表位的个体患AD的风险增加（分别为1.74（1.21，2.51）和1.48（1.04，2.12））。HLA-B*− 21 T（TT）前导序列增加了不同种族的AD风险。具有KIR 2DL 2、KIR 2DS 1、KIR 2DL 5和KIR 2DS 5的非裔美国人更可能患有AD，并且在适当的HLA-C C2表位存在下，KIR 2DS 1和KIR 2DS 5的风险增加。具有HLA-B*− 21 T前导序列的个体患AD的风险也增加。未来的研究应该集中在KIR基因等位基因变异以及考虑基于细胞的测量KIR和相关的HLA I类表位。
Atopic dermatitis (AD) is a chronic illness that is associated with immune dysregulation. Natural Killer (NK) cell function has previously been associated with AD. NK cells directly interact with polymorphic HLA Class I ligand variants utilizing killer cell immunoglobulin-like receptors (KIRs). The purpose of this study was to identify potential associations between NK cell function and AD by evaluating variation in the presence of KIR genes as well as KIR gene interactions with the appropriate HLA Class I KIR-specific ligands. Human DNA from the Genetics of Atopic Dermatitis case-control study was used to genotype HLA Class I KIR-specific ligands and the presence of KIR genes. In the full cohort, an increased risk of AD was noted for KIR2DL5 (1.51(1.13,2.01)), KIR2DS5 (1.72(1.26,2.34)), and KIR2DS1 (1.41 (1.04,1.91)). Individuals with KIR2DS5 or KIR2DS1 and the HLA-C*C2 epitope were at an increased risk of AD (1.74 (1.21,2.51) and 1.48 (1.04,2.12), respectively). The HLA-B*−21T (TT) leader sequence increased the risk of AD across ethnicity. African Americans with KIR2DL2, KIR2DS1, KIR2DL5 and KIR2DS5 are more likely to have AD and the risk increased for KIR2DS1 and KIR2DS5 in the presence of appropriate HLA-C C2 epitope. The risk of AD also increased for individuals with the HLA-B*−21T leader sequence. Future studies should focus on KIR gene allelic variation as well as consider cell-based measurements of KIR and the associated HLA Class I epitopes.
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影响因子：
--
作者：
Charman, CR;Venn, AJ;Williams, HC
通讯作者：
Williams, HC
影响因子：
6.5
作者：
JENSEN, JR;SAND, TT;THESTRUPPEDERSEN, K
通讯作者：
THESTRUPPEDERSEN, K
影响因子：
17.1
作者：
Mack, Madison R.;Brestoff, Jonathan R.;Kim, Brian S.
通讯作者：
Kim, Brian S.
DOI：
10.1002/iid3.178
发表时间：
2017-12
期刊：
Immunity, inflammation and disease
影响因子：
--
作者：
Blokhuis JH;Hilton HG;Guethlein LA;Norman PJ;Nemat-Gorgani N;Nakimuli A;Chazara O;Moffett A;Parham P
通讯作者：
Parham P
影响因子：
10.9
作者：
Chang, Joshua;Mitra, Nandita;Margolis, David J.
通讯作者：
Margolis, David J.