Brain function predictors and outcome of weight loss and weight loss maintenance.
Brain function predictors and outcome of weight loss and weight loss maintenance.
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大脑功能预测因素以及减肥和减肥维持的结果。
DOI：
10.1016/j.cct.2014.12.008
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发表时间：
2015
影响因子：
2.2
通讯作者：
Savag
中科院分区：
文献类型：
--
作者：
Szabo-Reed,AmandaN;Breslin,FlorenceJ;Lynch,AnthonyM;Patrician,TrishaM;Martin,LauraE;Lepping,RebeccaJ;Powell,JoshuaN;Yeh,Hung-WenHenry;Befort,ChristieA;Sullivan,Debra;Gibson,Cheryl;Washburn,Richard;Donnelly,JosephE;Savag
肥胖率与公共卫生后果和不断上升的医疗保健费用有关。减肥干预措施虽然有效，但并不适用于所有人，体重反弹是一个重大问题。饮食行为受到大脑中多种过程的影响，包括体内平衡因素和动机处理，这些因素是导致暴饮暴食的重要因素。最初的神经成像研究已经确定了肥胖和健康体重个体对视觉食物线索的不同反应的大脑区域，这些区域与肥胖参与者的饥饿报告呈正相关。虽然这些发现提供了暴饮暴食的机制，但仍然存在许多重要的问题。目前尚不清楚减肥后大脑激活模式是否会发生变化，或者它们是否会根据减肥量而发生差异。此外，人们对有助于长期体重维持的生物过程知之甚少。这项研究将在参与者观看食物和非食物图像时使用神经成像。功能性磁共振成像将在12周减肥干预完成前后进行。肥胖受试者将接受6个月的维持期随访。该研究将解决三个目标：1。描述肥胖个体食物动机和冲动行为背后的大脑激活。2.确定大脑激活变化和体重减轻的预测因素。3.确定大脑激活预测减肥维持。这项研究的发现将对理解肥胖、减肥和体重维持的机制产生影响。研究结果将对公众健康具有重要意义，并可能有助于更好地了解大脑激活的差异与肥胖的关系。
Obesity rates are associated with public health consequences and rising health care costs. Weight loss interventions, while effective, do not work for everyone, and weight regain is a significant problem. Eating behavior is influenced by a convergence of processes in the brain, including homeostatic factors and motivational processing that are important contributors to overeating. Initial neuroimaging studies have identified brain regions that respond differently to visual food cues in obese and healthy weight individuals that are positively correlated with reports of hunger in obese participants. While these findings provide mechanisms of overeating, many important questions remain. It is not known whether brain activation patterns change after weight loss, or if they change differentially based on amount of weight lost. Also, little is understood regarding biological processes that contribute to long-term weight maintenance. This study will use neuroimaging in participants while viewing food and non-food images. Functional Magnetic Resonance Imaging will take place before and after completion of a twelve-week weight loss intervention. Obese participants will be followed though a 6-month maintenance period. The study will address three aims: 1. Characterize brain activation underlying food motivation and impulsive behaviors in obese individuals. 2. Identify brain activation changes and predictors of weight loss. 3. Identify brain activation predictors of weight loss maintenance. Findings from this study will have implications for understanding mechanisms of obesity, weight loss, and weight maintenance. Results will be significant to public health and could lead to a better understanding of how differences in brain activation relate to obesity.
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影响因子：
5.7
作者：
Holsen, LM;Zarcone, JR;Savage, CR
通讯作者：
Savage, CR
影响因子：
4.9
作者：
Frankort, A.;Roefs, A.;Jansen, A.
通讯作者：
Jansen, A.
影响因子：
9.7
作者：
Finkelstein, Eric A.;Trogdon, Justin G.;Dietz, William
通讯作者：
Dietz, William
肥胖行为治疗中的食物供应与结构化膳食计划。
DOI：
--
发表时间：
1996
期刊：
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Wing,RR;Jeffery,RW;Burton,LR;Thorson,C;Nissinoff,KS;Baxter,JE
通讯作者：
Baxter,JE
成功的减肥计划对绝经后高危女性乳腺癌生物标志物的影响。
影响因子：
45.3
作者：
C. Fabian;J. Klemp;B. Kimler;Sonya Aversman;T. Phillips;C. Zalles;D. Sullivan;B. Smith;J. Donnelly;Henry Yeh
通讯作者：
Henry Yeh