Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts.
Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts.
复制标题
DOI：
10.1016/j.psyneuen.2013.09.024
复制
发表时间：
2014-01
影响因子：
3.7
通讯作者：
Kubzansky, Laura D.
中科院分区：
文献类型：
--
作者：
Chang, Shun-Chiao;Glymour, M. Maria;Rewak, Marissa;Cornelis, Marilyn C.;Walter, Stefan;Koenen, Karestan C.;Kawachi, Ichiro;Liang, Liming;Tchetgen, Eric J. Tchetgen;Kubzansky, Laura D.
一些证据表明，催产素途径基因的遗传多态性影响各种社会行为，但迄今为止的研究结果好坏参半。许多研究都是基于小样本，存在发表偏倚的可能性。使用来自美国 2 个大型前瞻性队列（超过 11,000 人）的数据，我们调查了 OXTR、AVPR1A 和 CD38 中与社会融合（以二元和连续形式的社会联系以及连续婚姻来衡量）相关的 88 个 SNP。经过多次测试校正后，CD38 中只有一个 SNP (rs12644506) 与社会融合显着相关，并且该 SNP 在使用社会联系二分指标时预测（调整后的 p=0.02），但不是社会联系或连续婚姻结果的连续测量。在一个 OXTR SNP 对二分社会联系的影响中发现了显着的性别异质效应；具体而言，rs4686302 T 等位基因名义上与男性的社会联系相关，而女性的关联方向相反（调整后的性别异质性 p=0.02）。此外，rs53576 A 等位基因仅在女性中与社会联系显着相关，并且在显性遗传模型中影响程度更强（调整后的 p=0.003）。总之，我们的研究结果表明，OXTR、CD38 和 AVPR1A 的常见遗传变异与本研究中使用简化的 Berkman-Syme 社交网络指数测量的社会融合无关，但这些发现和其他工作暗示，影响可能会因性别或其他社会经历而改变。如果能够更全面地评估这些额外因素，那么考虑与社会融合相关的遗传途径的进一步工作可能会更加富有成效。
Some evidence suggests that genetic polymorphisms in oxytocin pathway genes influence various social behaviors, but findings thus far have been mixed. Many studies have been based in small samples and there is possibility of publication bias. Using data from 2 large U.S. prospective cohorts with over 11,000 individuals, we investigated 88 SNPs in OXTR, AVPR1A, and CD38, in relation to social integration (measured as social connectedness in both binary and continuous forms and being continuously married). After correction for multiple testing only one SNP in CD38 (rs12644506) was significantly associated with social integration and that SNP predicted when using a dichotomized indicator of social connectedness (adjusted p=0.02), but not a continuous measure of social connectedness or the continuously married outcome. A significant gender-heterogeneous effect was identified in one OXTR SNP on dichotomized social connectedness; specifically, rs4686302 T allele was nominally associated with social connectedness in men, whereas the association direction was opposite in women (adjusted gender heterogeneity p=0.02). Furthermore, the rs53576 A allele was significantly associated with social connectedness only in women, and the effect magnitude was stronger in a dominant genetic model (adjusted p=0.003). In summary, our findings suggested that common genetic variants of OXTR, CD38, and AVPR1A are not associated with social integration as measured in this study using the simplified Berkman-Syme Social Network Index, but these findings and other work hint that effects may be modified by gender or other social experiences. Further work considering genetic pathways in relation to social integration may be more fruitful if these additional factors can be more comprehensively evaluated.
登录
查看更多内容
影响因子：
16.2
作者：
Insel, Thomas R.
通讯作者：
Insel, Thomas R.
影响因子：
10.6
作者：
Gordon, Ilanit;Zagoory-Sharon, Orna;Leckman, James F.;Feldman, Ruth
通讯作者：
Feldman, Ruth
影响因子：
1.9
作者：
Gabor, Christopher S.;Phan, Anna;Choleris, Elena
通讯作者：
Choleris, Elena
影响因子：
5
作者：
Eng, PM;Rimm, EB;Kawachi, I
通讯作者：
Kawachi, I
DOI：
10.1073/pnas.1010830107
发表时间：
2010-09-07
影响因子：
11.1
作者：
Kim, Heejung S.;Sherman, David K.;Taylor, Shelley E.
通讯作者：
Taylor, Shelley E.