Human Tissue-Resident Memory T Cells in the Maternal-Fetal Interface. Lost Soldiers or Special Forces?
Human Tissue-Resident Memory T Cells in the Maternal-Fetal Interface. Lost Soldiers or Special Forces?
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作者：
DeJong CS;Maurice NJ;McCartney SA;Prlic M
免疫系统在怀孕期间发挥着关键作用，但支持怀孕所需的具体机制和免疫细胞功能仍未完全清楚。尽管进行了数十年的研究，但目前仍不清楚免疫系统如何在不丧失抵御有害感染的能力的情况下，维持对胎儿来源组织的耐受性，这些组织包括胎盘的大部分细胞，当然还有胎儿本身。T细胞在主要组织相容性复合体(MHC)编码蛋白的背景下识别抗原，但在胎儿来源的细胞中经典的MHC I和II类表达减少。位于母胎界面(MFI)的T细胞能保护这些细胞免受感染吗？在这里，我们回顾了关于MFI的组织驻留记忆T(Trm)细胞的已知情况。我们主要关注Trm细胞如何在MFI的独特特征的背景下发挥保护作用，例如MHC的有限表达以及MFI的临时性，这些都是其他组织中没有的。
The immune system plays a critical role during pregnancy, but the specific mechanisms and immune cell function needed to support pregnancy remain incompletely understood. Despite decades of research efforts, it is still unclear how the immune system maintains tolerance of fetal-derived tissues, which include most cells of the placenta and of course the fetus itself, without forfeiting the ability to protect against harmful infections. T cells recognize antigen in the context of major histocompatibility complex (MHC) encoded proteins, but classical MHC class I and II expression are diminished in fetal-derived cells. Can T cells present at the maternal–fetal interface (MFI) protect these cells from infection? Here we review what is known in regard to tissue-resident memory T (Trm) cells at the MFI. We mainly focus on how Trm cells can contribute to protection in the context of the unique features of the MFI, such as limited MHC expression as well as the temporary nature of the MFI, that are not found in other tissues.
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DOI：
10.1111/aji.12623
发表时间：
2017-03
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
Anders AP;Gaddy JA;Doster RS;Aronoff DM
通讯作者：
Aronoff DM
影响因子：
8.8
作者：
Chu T;Tyznik AJ;Roepke S;Berkley AM;Woodward-Davis A;Pattacini L;Bevan MJ;Zehn D;Prlic M
通讯作者：
Prlic M
妊娠早期人类蜕膜中存在具有独特性质的组织驻留 CD8( )T 记忆细胞
影响因子：
3.6
作者：
Huang, Xixi;Liu, Lu;Du, Meirong
通讯作者：
Du, Meirong
影响因子：
3.4
作者：
Crespo ÂC;van der Zwan A;Ramalho-Santos J;Strominger JL;Tilburgs T
通讯作者：
Tilburgs T
影响因子：
17.1
作者：
Clark RA;Watanabe R;Teague JE;Schlapbach C;Tawa MC;Adams N;Dorosario AA;Chaney KS;Cutler CS;Leboeuf NR;Carter JB;Fisher DC;Kupper TS
通讯作者：
Kupper TS