Palette of Rechargeable Mechanoluminescent Fluids Produced by a Biomineral-Inspired Suppressed Dissolution Approach.
Palette of Rechargeable Mechanoluminescent Fluids Produced by a Biomineral-Inspired Suppressed Dissolution Approach.
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DOI：
10.1021/jacs.2c06724
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发表时间：
2022-10-12
影响因子：
15
通讯作者：
Hong, Guosong
中科院分区：
文献类型：
--
作者：
Yang, Fan;Wu, Xiang;Cui, Han;Jiang, Shan;Ou, Zihao;Cai, Sa;Hong, Guosong
机械发光材料响应于机械刺激而发光，最近已被探索为光子皮肤、远程光遗传学和压力传感的有希望的候选者。迄今为止报道的所有机械发光材料都是具有微米级颗粒的块状固体，并且它们的光发射仅在块状形式断裂或变形时产生。相比之下，在液体和胶体溶液中从未观察到机械发光，因此限制了其在生物体中的生物应用。在这里，我们报告的机械发光流体的合成通过抑制溶解的方法。我们证明，这种方法产生稳定的胶体溶液，包括机械发光纳米晶体与明亮的发射范围为470-610 nm和直径下降到20 nm。这些胶体溶液可以分别在光激发和流体动力学聚焦超声下重复充电和放电，从而产生可以以可逆方式存储光子能量的可充电机械发光流体。这种可再充电流体可以促进由组织穿透超声门控的全身递送光源，用于需要组织中的光的生物应用，例如大脑中的光遗传学刺激。
Mechanoluminescent materials, which emit light in response to mechanical stimuli, have recently been explored as promising candidates for photonic skins, remote optogenetics, and stress sensing. All mechanoluminescent materials reported thus far are bulk solids with microns-sized grains, and their light emission is only produced when fractured or deformed in bulk form. In contrast, mechanoluminescence has never been observed in liquids and colloidal solutions, thus limiting its biological application in living organisms. Here we report the synthesis of mechanoluminescent fluids via a suppressed dissolution approach. We demonstrate that this approach yields stable colloidal solutions comprising mechanoluminescent nanocrystals with bright emission in the range of 470–610 nm and diameters down to 20 nm. These colloidal solutions can be recharged and discharged repeatedly under photoexcitation and hydrodynamically focused ultrasound, respectively, thus yielding rechargeable mechanoluminescent fluids that can store photon energy in a reversible manner. This rechargeable fluid can facilitate a systemically delivered light source gated by tissue-penetrant ultrasound for biological applications that require light in the tissue, such as optogenetic stimulation in the brain.
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