Metformin Enhances B Cell Function and Antibody Responses of Elderly Individuals With Type-2 Diabetes Mellitus.
Metformin Enhances B Cell Function and Antibody Responses of Elderly Individuals With Type-2 Diabetes Mellitus.
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DOI：
10.3389/fragi.2021.715981
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发表时间：
2021
影响因子：
--
通讯作者：
Blomberg, Bonnie B.
中科院分区：
文献类型：
--
作者：
Frasca, Daniela;Diaz, Alain;Romero, Maria;Blomberg, Bonnie B.
我们以前的工作表明，接受二甲双胍治疗的年轻和老年2型糖尿病（T2DM）患者具有最佳的B细胞功能和季节性流感疫苗特异性血清抗体。在本文中，我们评估了B细胞功能和B细胞抗体应答的代谢要求，在老年T2 DM患者（ET2 DM）服用或不服用二甲双胍，并与健康老年人（EH）和健康年轻人（YH）进行了比较。结果显示，Metabolic显著增加体内B细胞功能，通过流感疫苗特异性血清抗体测量，在ET 2 DM患者中达到在EH中观察到的水平，更重要的是在YH个体中观察到的水平。二甲双胍还降低促炎性B细胞亚群的频率，以及ET 2 DM的外周B细胞的内在炎症和代谢需求。需要来自ET 2 DM的B细胞的这种高代谢表型来支持内在炎症，通过衰老相关分泌表型（SASP）的标记物的转录物的表达和自身免疫抗体的分泌来测量。重要的是，服用二甲双胍的ET 2 DM患者中的B细胞功能不仅与未服用二甲双胍的ET 2 DM患者相比增加，而且与YH个体中测量的B细胞功能相当。这些结果共同有力地支持了二甲双胍对体液免疫的抗衰老作用。
Our previous work has shown that young and elderly patients with Type-2 Diabetes Mellitus (T2DM) treated with Metformin have optimal B cell function and serum antibodies specific for the seasonal influenza vaccine. In this paper, we have evaluated B cell function and the metabolic requirements of B cell antibody responses in elderly T2DM patients (ET2DM) taking or not Metformin, and compared to those of healthy elderly (EH) and healthy young (YH) individuals. Results show that Metformin significantly increases in vivo B cell function, measured by influenza vaccine-specific serum antibodies, in ET2DM patients to the levels observed in EH and more importantly in YH individuals. Metformin also decreases the frequencies of pro-inflammatory B cell subsets, as well as intrinsic inflammation and metabolic requirements of peripheral B cells from ET2DM. This hyper-metabolic phenotype of B cells from ET2DM is needed to support intrinsic inflammation, measured by the expression of transcripts for markers of the senescence-associated secretory phenotype (SASP), and the secretion of autoimmune antibodies. Importantly, B cell function in ET2DM patients taking Metformin is not only increased as compared to that in ET2DM patients not taking Metformin, but is comparable to B cell function measured in YH individuals. These results altogether strongly support the anti-aging effects of Metformin on humoral immunity.
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DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
4.4
作者：
Frasca, Daniela;Diaz, Alain;Blomberg, Bonnie B.
通讯作者：
Blomberg, Bonnie B.
影响因子：
7.3
作者：
Frasca D;Diaz A;Romero M;Blomberg BB
通讯作者：
Blomberg BB
影响因子：
5.6
作者：
Frasca D;Romero M;Diaz A;Garcia D;Thaller S;Blomberg BB
通讯作者：
Blomberg BB
影响因子：
3.7
作者：
Frasca, Daniela;Diaz, Alain;Blomberg, Bonnie B.
通讯作者：
Blomberg, Bonnie B.