Offspring neuroimmune consequences of maternal malnutrition: Potential mechanism for behavioral impairments that underlie metabolic and neurodevelopmental disorders.
Offspring neuroimmune consequences of maternal malnutrition: Potential mechanism for behavioral impairments that underlie metabolic and neurodevelopmental disorders.
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DOI：
10.1016/j.yfrne.2017.07.007
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发表时间：
2017-10
影响因子：
7.4
通讯作者：
Reyes TM
中科院分区：
文献类型：
--
作者：
Smith BL;Reyes TM
母亲营养不良显著增加后代患代谢和神经发育障碍的风险。母体营养不良的动物模型已经确定了与执行功能和奖励处理相关的成年后代的行为变化。总之，这些变化的执行和奖励为基础的行为可能有助于代谢和神经发育障碍与产妇营养不良的病因。伴随着行为的影响，母亲营养不良改变后代表达的奖励相关分子和炎症信号的大脑通路，控制执行功能和奖励。这些特定脑回路中的神经免疫通路和小胶质细胞相互作用，无论是在早期发育还是成年后期，都可能直接导致母体营养不良诱导的行为表型。了解这些机制将有助于推进代谢和神经发育障碍的治疗策略，特别是非侵入性膳食补充干预。
Maternal malnutrition significantly increases offspring risk for both metabolic and neurodevelopmental disorders. Animal models of maternal malnutrition have identified behavioral changes in the adult offspring related to executive function and reward processing. Together, these changes in executive and reward-based behaviors likely contribute to the etiology of both metabolic and neurodevelopmental disorders associated with maternal malnutrition. Concomitant with the behavioral effects, maternal malnutrition alters offspring expression of reward-related molecules and inflammatory signals in brain pathways that control executive function and reward. Neuroimmune pathways and microglial interactions in these specific brain circuits, either in early development or later in adulthood, could directly contribute to the maternal malnutrition-induced behavioral phenotypes. Understanding these mechanisms will help advance treatment strategies for metabolic and neurodevelopmental disorders, especially noninvasive dietary supplementation interventions.
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