Sexually dimorphic responses to early adversity: implications for affective problems and autism spectrum disorder.
Sexually dimorphic responses to early adversity: implications for affective problems and autism spectrum disorder.
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DOI：
10.1016/j.psyneuen.2014.06.014
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发表时间：
2014-11
影响因子：
3.7
通讯作者：
Pfaff, Donald
中科院分区：
文献类型：
--
作者：
Davis, Elysia Poggi;Pfaff, Donald
关键词：
在妊娠期，发育的速度是生命周期中任何其他阶段都无法比拟的。由于这些原因，人类胎儿不仅特别容易受到组织影响，而且也特别容易受到致病性破坏影响。越来越多的证据表明，产前逆境会导致神经系统的变化，而这些变化是终身患精神疾病的风险的基础。从妊娠早期开始，男性和女性表现出不同的发育轨迹和对压力的反应。这是可能的，在胎儿时期的神经回路的性别依赖性组织影响不同的脆弱性心理健康问题。我们认为，在这篇评论的证据表明，性二型反应的早期生活压力与两个发展障碍：情感问题（更大的女性患病率）和自闭症谱系障碍（更大的男性患病率）。最近的前瞻性研究，说明胎儿暴露于压力和应激激素的男性和女性的神经发育的后果被认为是在这里。合理的生物学机制，包括性分化胎盘的作用进行了讨论。我们认为，在这篇评论的证据表明，性二型反应的早期生活压力与两组发展障碍：情感问题（女性患病率更高）和自闭症谱系障碍（男性患病率更高）。
During gestation, development proceeds at a pace that is unmatched by any other stage of the lifecycle. For these reason the human fetus is particularly susceptible not only to organizing influences, but also to pathogenic disorganizing influences. Growing evidence suggests that exposure to prenatal adversity leads to neurological changes that underlie lifetime risks for mental illness. Beginning early in gestation, males and females show differential developmental trajectories and responses to stress. It is likely that sex-dependent organization of neural circuits during the fetal period influences differential vulnerability to mental health problems. We consider in this review evidence that sexually dimorphic responses to early life stress are linked to two developmental disorders: affective problems (greater female prevalence) and autism spectrum disorder (greater male prevalence). Recent prospective studies illustrating the neurodevelopmental consequences of fetal exposure to stress and stress hormones for males and females are considered here. Plausible biological mechanisms including the role of the sexually differentiated placenta are discussed. We consider in this review evidence that sexually dimorphic responses to early life stress are linked to two sets of developmental disorders: affective problems (greater female prevalence) and autism spectrum disorders (greater male prevalence).
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影响因子：
10.6
作者：
Davis, Elysia Poggi;Sandman, Curt A;Buss, Claudia;Wing, Deborah A;Head, Kevin
通讯作者：
Head, Kevin
DOI：
10.3109/10253890.2011.623250
发表时间：
2011-11
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Buss C;Davis EP;Hobel CJ;Sandman CA
通讯作者：
Sandman CA
影响因子：
15.1
作者：
Babri, Shirin;Doosti, Mohammad-Hossein;Salari, Ali-Akbar
通讯作者：
Salari, Ali-Akbar
DOI：
10.1073/pnas.1106022108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Broad, Kevin D.;Keverne, Eric B.
通讯作者：
Keverne, Eric B.
影响因子：
--
作者：
Bekker, Marrie H. J.;van Mens-Verhulst, Janneke
通讯作者：
van Mens-Verhulst, Janneke