Emerging role of nanomaterials in circulating tumor cell isolation and analysis.
Emerging role of nanomaterials in circulating tumor cell isolation and analysis.
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DOI：
10.1021/nn5004277
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发表时间：
2014-03-25
期刊：
影响因子：
17.1
通讯作者：
Nagrath, Sunitha
中科院分区：
文献类型：
--
作者：
Yoon, Hyeun Joong;Kozminsky, Molly;Nagrath, Sunitha
关键词：
循环肿瘤细胞（CTC）是从原发性肿瘤脱落后在血流中发现的低频细胞。这些细胞成为研究目标，因为它们可能提供有关个体癌症以及癌症在转移过程中扩散机制的信息。 CTC 分离已有成熟的技术，但该领域的最新进展和未来在于纳米材料。在这篇综述中，我们提供了对历史 CTC 捕获以及当前正在进行的研究的看法，强调了用于制造这些设备的材料的重要性。对 CTC 的现代研究最初采用的技术现已商业化。该领域的一项重大创新是微流体捕获装置的开发，该装置首先采用硅制造，随后采用玻璃和热聚合物装置。然后，我们特别强调结合磁性纳米颗粒、碳纳米管、纳米线、纳米柱、纳米纤维和纳米粗糙表面、氧化石墨烯的技术及其制造方法。纳米尺度提供了一套新的工具，有可能克服当前与 CTC 捕获和分析相关的限制。我们相信该领域目前的发展轨迹是纳米材料的方向，从而可以进行必要的改进以进一步进行 CTC 研究。
Circulating tumor cells (CTCs) are low frequency cells found in the bloodstream after having been shed from a primary tumor. These cells are research targets because of the information they may potentially provide about both an individual cancer as well as the mechanisms through which cancer spreads in the process of metastasis. Established technologies exist for CTC isolation, but the recent progress and future of this field lie in nanomaterials. In this review, we provide perspective into historical CTC capture as well as current research being conducted, emphasizing the significance of the materials being used to fabricate these devices. The modern investigation into CTCs initially featured techniques that have since been commercialized. A major innovation in the field was the development of a microfluidic capture device, first fabricated in silicon and followed up with glass and thermopolymer devices. We then specifically highlight the technologies incorporating magnetic nanoparticles, carbon nanotubes, nanowires, nanopillars, nanofibers, and nanoroughened surfaces, graphene oxide and their fabrication methods. The nanoscale provides a new set of tools that has the potential to overcome current limitations associated with CTC capture and analysis. We believe the current trajectory of the field is in the direction of nanomaterials, allowing the improvements necessary to further CTC research.
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影响因子：
45.3
作者：
Cristofanilli, M;Hayes, DF;Terstappen, LWMM
通讯作者：
Terstappen, LWMM
影响因子：
158.5
作者：
Cristofanilli, M;Budd, GT;Hayes, DF
通讯作者：
Hayes, DF
影响因子：
6.1
作者：
Earhart CM;Hughes CE;Gaster RS;Ooi CC;Wilson RJ;Zhou LY;Humke EW;Xu L;Wong DJ;Willingham SB;Schwartz EJ;Weissman IL;Jeffrey SS;Neal JW;Rohatgi R;Wakelee HA;Wang SX
通讯作者：
Wang SX
用于少细胞富集和检测的石墨涂层磁性纳米颗粒微阵列
影响因子：
17.1
作者：
Chen, Zhuo;Hong, Guosong;Dai, Hongjie
通讯作者：
Dai, Hongjie
DOI：
10.1158/1078-0432.ccr-10-2650
发表时间：
2011-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Danila DC;Fleisher M;Scher HI
通讯作者：
Scher HI