Aging and gene expression in the primate brain.
Aging and gene expression in the primate brain.
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DOI：
10.1371/journal.pbio.0030274
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发表时间：
2005-09
期刊：
影响因子：
9.8
通讯作者：
Eisen MB
中科院分区：
文献类型：
--
作者：
Fraser HB;Khaitovich P;Plotkin JB;Pääbo S;Eisen MB
众所周知，许多生物体中的基因表达水平在衰老过程中会发生变化，DNA微阵列的出现使得在模型生物和各种人体组织中研究与衰老相关的全基因组转录变化模式成为可能。了解衰老对人类大脑中基因表达的影响特别有趣，因为它与正常和病理性神经变性有关。在这里，我们表明，人类大脑皮层，人类小脑和黑猩猩皮层每个经历不同的模式与年龄相关的基因表达改变。在人类中，更多的基因在皮层中经历了一致的表达变化，而不是在小脑中;在黑猩猩中，许多基因随着年龄的增长而改变皮层的表达，但表达变化的模式与人类皮层几乎没有相似之处。这些结果证明了人类大脑中存在的衰老模式的多样性，以及全基因组衰老模式在物种之间的进化速度;它们也可能对衰老的氧化自由基理论产生影响，并有助于提高我们对人类神经退行性疾病的理解。人类和黑猩猩的转录谱揭示了人类大脑中存在的衰老模式的多样性，以及物种之间全基因组衰老模式的演变速度。
It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes associated with aging to be studied in both model organisms and various human tissues. Understanding the effects of aging on gene expression in the human brain is of particular interest, because of its relation to both normal and pathological neurodegeneration. Here we show that human cerebral cortex, human cerebellum, and chimpanzee cortex each undergo different patterns of age-related gene expression alterations. In humans, many more genes undergo consistent expression changes in the cortex than in the cerebellum; in chimpanzees, many genes change expression with age in cortex, but the pattern of changes in expression bears almost no resemblance to that of human cortex. These results demonstrate the diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species; they may also have implications for the oxidative free radical theory of aging, and help to improve our understanding of human neurodegenerative diseases. Transcriptional profiles in human and chimpanzee reveal a diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species.
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影响因子：
6.1
作者：
Evans, SJ;Choudary, PV;Akil, H
通讯作者：
Akil, H
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
9.8
作者：
Rodwell GE;Sonu R;Zahn JM;Lund J;Wilhelmy J;Wang L;Xiao W;Mindrinos M;Crane E;Segal E;Myers BD;Brooks JD;Davis RW;Higgins J;Owen AB;Kim SK
通讯作者：
Kim SK
影响因子：
30.8
作者：
Lee, CK;Weindruch, R;Prolla, TA
通讯作者：
Prolla, TA
影响因子：
3.5
作者：
Li, JZ;Vawter, MP;Myers, RM
通讯作者：
Myers, RM