All-cause and cause-specific mortality in people with mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study.
All-cause and cause-specific mortality in people with mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study.
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DOI：
10.1016/j.lanepe.2021.100228
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Stewart R
中科院分区：
文献类型：
--
作者：
Das-Munshi J;Chang CK;Bakolis I;Broadbent M;Dregan A;Hotopf M;Morgan C;Stewart R
与一般人口相比，精神障碍和智力残疾者的死亡率较高。COVID-19对加剧这种情况以及扩大种族不平等的影响尚不清楚。前瞻性数据（N= 167，122），来自英国伦敦的一家大型精神卫生保健提供商，2019年至2020年的死亡人数，用于评估9种精神疾病的年龄和性别标准化死亡率（SMR）（精神分裂症谱系障碍、情感障碍、躯体形式/神经症性障碍、人格障碍、学习障碍、进食障碍、物质使用障碍，广泛性发育障碍、痴呆症）和种族。在世界卫生组织（世卫组织）于二零二零年一月三十日宣布COVID-19为突发公共卫生事件之前，所有精神科队列的全因SMR均为一般人群的两倍以上。到2020年第二季度，当英国经历COVID-19死亡人数的大幅高峰时，全因SMR进一步增加，COVID-19 SMR在所有条件下都有所上升（特别是：学习障碍：SMR：9.24（95% CI：5.98-13.64），广泛性发育障碍：5.01（95% CI：2.40-9.20），进食障碍：4.81（95% CI：1.56-11.22），精神分裂症谱系疾病：3.26（95%CI：2.55-4.10），痴呆：3.82（95%CI：3.42，4.25），人格障碍：4.58（95%CI：3.09-6.53））。全年其他原因造成的死亡人数仍然至少是人口平均数的两倍。各族裔群体的最低限度标准比率增加情况相似。在COVID-19死亡的第一个高峰期之前、期间和之后，精神障碍和智力障碍患者的死亡风险相对于普通人群更高，种族风险相似。非COVID-19 ╱其他原因导致的死亡率在疫情前╱期间有所上升，其中COVID-19死亡率在疫情期间更高。ESRC（JD、CM）、NIHR（JD、RS、MH）、健康基金会（JD）、GSK、杨森、武田（RS）。
People with mental disorders and intellectual disabilities experience excess mortality compared with the general population. The impact of COVID-19 on exacerbating this, and in widening ethnic inequalities, is unclear. Prospective data (N=167,122) from a large mental healthcare provider in London, UK, with deaths from 2019 to 2020, used to assess age- and gender-standardised mortality ratios (SMRs) across nine psychiatric conditions (schizophrenia-spectrum disorders, affective disorders, somatoform/ neurotic disorders, personality disorders, learning disabilities, eating disorders, substance use disorders, pervasive developmental disorders, dementia) and by ethnicity. Prior to the World Health Organization (WHO) declaring COVID-19 a public health emergency on 30th January 2020, all-cause SMRs across all psychiatric cohorts were more than double the general population. By the second quarter of 2020, when the UK experienced substantial peaks in COVID-19 deaths, all-cause SMRs increased further, with COVID-19 SMRs elevated across all conditions (notably: learning disabilities: SMR: 9.24 (95% CI: 5.98-13.64), pervasive developmental disorders: 5.01 (95% CI: 2.40-9.20), eating disorders: 4.81 (95% CI: 1.56-11.22), schizophrenia-spectrum disorders: 3.26 (95% CI: 2.55-4.10), dementia: 3.82 (95% CI: 3.42, 4.25) personality disorders 4.58 (95% CI: 3.09-6.53)). Deaths from other causes remained at least double the population average over the whole year. Increased SMRs were similar across ethnic groups. People with mental disorders and intellectual disabilities were at a greater risk of deaths relative to the general population before, during and after the first peak of COVID-19 deaths, with similar risks by ethnicity. Mortality from non-COVID-19/ other causes was elevated before/ during the pandemic, with higher COVID-19 mortality during the pandemic. ESRC (JD, CM), NIHR (JD, RS, MH), Health Foundation (JD), GSK, Janssen, Takeda (RS).
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DOI：
10.1016/j.jagp.2020.09.016
发表时间：
2020-12
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
--
作者：
Lee DY;Cho J;You SC;Park RW;Kim CS;Lee EY;Aizenstein H;Andreescu C;Karim H;Hong CH;Rho HW;Park B;Son SJ
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DOI：
10.1016/s2215-0366(20)30434-x
发表时间：
2020-12
期刊：
The lancet. Psychiatry
影响因子：
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DOI：
10.1136/bmj.f2539
发表时间：
2013-05-21
期刊：
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影响因子：
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作者：
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影响因子：
6.9
作者：
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25.8
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