Rapid increase in Omicron infections in England during December 2021: REACT-1 study.

Rapid increase in Omicron infections in England during December 2021: REACT-1 study.
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DOI:
10.1126/science.abn8347
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发表时间:
2022-03-25
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Donnelly CA
Donnelly CA
中科院分区:
其他
文献类型:
--
作者:
Elliott P;Bodinier B;Eales O;Wang H;Haw D;Elliott J;Whitaker M;Jonnerby J;Tang D;Walters CE;Atchison C;Diggle PJ;Page AJ;Trotter AJ;Ashby D;Barclay W;Taylor G;Ward H;Darzi A;Cooke GS;Chadeau-Hyam M;Donnelly CA

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2021年12月,SARS-CoV-2感染人数史无前例地上升,同时奥米克龙变异病毒在英国和全球迅速传播。我们分析了2021年11月底至12月中旬期间SARS-CoV-2在英国的流行情况及其动态,参与研究的近10万人参与了REPACT-1研究。2021年12月,感染率很高,全国特别是伦敦的发病率迅速增长,由于奥美康而感染的比例越来越高。我们观察到,在主要接种疫苗的大龄儿童(12-17岁)中,与未接种疫苗的较小儿童(5-11岁)相比,拭子阳性率大幅下降,在接受第三剂(加强)疫苗接种的成年人中,与接种两剂疫苗的成年人相比,下降幅度较大。我们的结果加强了疫苗接种和加强运动的重要性,尽管需要采取更多措施来控制奥米克隆变种的快速增长。
The unprecedented rise in SARS-CoV-2 infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed prevalence of SARS-CoV-2 and its dynamics in England from end November to mid-December 2021 among almost 100,000 participants from the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, and an increasing proportion of infections due to Omicron. We observed large falls in swab positivity among mostly vaccinated older children (12-17 years) compared with unvaccinated younger children (5-11 years), and in adults who received a third (booster) vaccine dose vs. two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.
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