Testosterone protects against the development of widespread muscle pain in mice.
Testosterone protects against the development of widespread muscle pain in mice.
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睾丸素可以防止老鼠出现大面积的肌肉疼痛。
DOI：
10.1097/j.pain.0000000000001985
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发表时间：
2020-12
期刊：
影响因子：
7.4
通讯作者：
Sluka KA
中科院分区：
文献类型：
--
作者：
Lesnak JB;Inoue S;Lima L;Rasmussen L;Sluka KA
慢性广泛性疼痛在女性中比男性更普遍，这表明性腺激素在观察到的差异中起着重要作用。先前，我们在活动引起的肌肉疼痛模型中发现，与雄性小鼠相比，雌性小鼠出现了广泛、更严重、持续时间更长的痛觉过敏。我们假设睾酮可以保护雄性免受雌性疼痛表型的影响。我们测试了在诱导活动性疼痛模型之前，男性的睾丸切除术是否会产生女性表型，以及睾酮治疗是否会在女性中产生男性表型。睾丸切除术产生更持久，更广泛的痛觉过敏，类似于女性。给雌性或切除睾丸的雄性注射睾酮会产生单侧、短时间的痛觉过敏。先前的研究表明，慢性疼痛模型中缝大核（NRM）中的血清素转运体（SERT）增加，阻断NRM中的SERT可减轻痛觉过敏。我们使用免疫组织化学检查了SERT在涉及伤害性加工的大脑部位分布的潜在性别差异。在活动性疼痛模型中，NRM的SERT存在性别差异；女性的sert免疫反应性高于男性。这表明睾酮可以防止广泛、持久的肌肉疼痛的发展，SERT的改变可能是性别差异的基础。
Chronic widespread pain conditions are more prevalent in women than men suggesting a role for gonadal hormones in the observed differences. Previously, we showed female mice, compared to male, develop widespread, more severe, and longer duration hyperalgesia in a model of activity-induced muscle pain. We hypothesized testosterone protects males from developing the female pain phenotype. We tested if orchiectomy of males prior to induction of an activity-induced pain model produced a female phenotype and if testosterone administration produced a male phenotype in females. Orchiectomy produced longer lasting, more widespread hyperalgesia, similar to females. Administration of testosterone to females or orchiectomized males produced unilateral, shorter lasting hyperalgesia. Prior studies show that the serotonin transporter (SERT) is increased in the nucleus raphe magnus (NRM) in models of chronic pain, and that blockade of SERT in the NRM reduces hyperalgesia. We examined potential sex differences in the distribution of SERT across brain sites involved in nociceptive processing using immunohistochemistry. A sex difference in SERT was found in the NRM in the activity-induced pain model; females had greater SERT-immunoreactivity than males. This suggests testosterone protects against development of widespread, long-lasting muscle pain and that alterations in SERT may underlie the sex differences.
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影响因子：
3.6
作者：
Ito H;Yanase M;Yamashita A;Kitabatake C;Hamada A;Suhara Y;Narita M;Ikegami D;Sakai H;Yamazaki M;Narita M
通讯作者：
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作者：
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通讯作者：
Lee, Y. D.
影响因子：
7.4
作者：
Dessein, PH;Shipton, EA;Van der Merwe, BA
通讯作者：
Van der Merwe, BA