Induction of anti-tumor immunity by mouse tumor cells transfected with mouse interleukin-12 gene.
Induction of anti-tumor immunity by mouse tumor cells transfected with mouse interleukin-12 gene.
复制标题
转染小鼠白细胞介素12基因的小鼠肿瘤细胞诱导抗肿瘤免疫。
DOI：
10.7883/yoken1952.48.221
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
H. Yamamoto
中科院分区：
文献类型：
--
作者：
S. Obana;H. Miyazawa;E. Hara;T. Tamura;H. Nariuchi;M. Takata;S. Fujimoto;H. Yamamoto
Interleukin-12 (IL-12) is a heterodimeric cytokine. In order to transduce both cDNAs for p35 and p40 of IL-12 in the tumor cells, a polycistronic retroviral vector was constructed by inserting the internal ribosome entry site gene of encephalomyocarditis virus between two cDNAs. On the other hand, two cDNAs were sequentially transfected in the tumor cells. Both polycistronic gene transfectants and double transfectants produced biologically active mouse IL-12. IL-12-expressing tumor cells were all rejected in syngeneic mice, and induced cytotoxic T lymphocyte activity. The capacity to induce anti-tumor memory may depend on the amount of IL-12 produced by the transfectants, because the relatively higher IL-12 producer tumor cell line induced the anti-tumor memory in the rejected mice, but the lower producer did not.
登录
查看更多内容
影响因子：
4.4
作者：
B. Perussia;S. Chan;Annalisa D'Andrea;K. Tsuji;D. Santoli;M. Pospíšil;D. Young;S. Wolf;Giorgio Trinchieri
通讯作者：
B. Perussia;S. Chan;Annalisa D'Andrea;K. Tsuji;D. Santoli;M. Pospíšil;D. Young;S. Wolf;Giorgio Trinchieri
影响因子：
4.4
作者：
M. Sarmiento;A. Glasebrook;F. Fitch
通讯作者：
M. Sarmiento;A. Glasebrook;F. Fitch
通过单克隆抗体 GK1.5 鉴定的鼠 T 细胞表面分子（称为 L3T4）的特征：L3T4 与人 Leu-3/T4 分子的相似性。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Dialynas,DP;Quan,ZS;Wall,KA;Pierres,A;Quintans,J;Loken,MR;Pierres,M;Fitch,FW
通讯作者：
Fitch,FW
影响因子：
4.4
作者：
S. Wolf;P. Temple;Michiko Kobayashi;D. Young;M. Dicig;L. Lowe;R. Dzialo;L. Fitz;C. Ferenz;R. Hewick
通讯作者：
S. Wolf;P. Temple;Michiko Kobayashi;D. Young;M. Dicig;L. Lowe;R. Dzialo;L. Fitz;C. Ferenz;R. Hewick
经过基因工程改造后分泌白细胞介素 12 的成纤维细胞可以抑制肿瘤生长，并在体内诱导针对小鼠黑色素瘤的抗肿瘤免疫。
影响因子：
11.2
作者：
Tahara,H;Zeh3rd,HJ;Storkus,WJ;Pappo,I;Watkins,SC;Gubler,U;Wolf,SF;Robbins,PD;Lotze,MT
通讯作者：
Lotze,MT