Changes in spinal cord hemodynamics reflect modulation of spinal network with different parameters of epidural stimulation.
Changes in spinal cord hemodynamics reflect modulation of spinal network with different parameters of epidural stimulation.
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DOI：
10.1016/j.neuroimage.2020.117183
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发表时间：
2020-11-01
期刊：
影响因子：
5.7
通讯作者：
Lavrov IA
中科院分区：
文献类型：
--
作者：
Tang S;Cuellar CA;Song P;Islam R;Huang C;Wen H;Knudsen BE;Gong P;Lok UW;Chen S;Lavrov IA
本研究利用功能超声(FUS)优越的时空分辨率，对硬膜外电刺激引起的局部血流动力学反应进行了研究，并实时研究了脊髓功能的变化。通过量化血流动力学和肌电反应特征，我们验证了脊髓对硬膜外电刺激的瞬时血流动力学反应可以反映脊髓回路的调制，从而对电刺激参数的变化做出反应的假说。这项研究的结果首次表明，对电刺激的血流动力学反应可以反映脊髓的神经-血管耦合。与腹侧脊髓相比，背侧区域对硬膜外刺激的反应明显更高和更快。在较低的硬膜外刺激频率(20和40赫兹)下，血流动力学与肌电反应呈正相关，根据我们以前的研究结果，与较高频率(200和500赫兹)相比，硬膜外刺激可以促进脊髓损伤后的脊髓环路。这些结果提示，不同电刺激参数下脊髓血流动力学变化可能涉及不同的机制，并首次提供了脊髓环路的神经-血管耦合可能与脊髓血管和血流动力学的特定组织有关的证据。
In this study functional ultrasound (fUS) imaging has been implemented to explore the local hemodynamics response induced by electrical epidural stimulation and to study real-time in vivo functional changes of the spinal cord, taking advantage of the superior spatiotemporal resolution provided by fUS. By quantifying the hemodynamics and electromyographic response features, we tested the hypothesis that the temporal hemodynamics response of the spinal cord to electrical epidural stimulation could reflect modulation of the spinal circuitry and accordingly respond to the changes in parameters of electrical stimulation. The results of this study for the first time demonstrate that the hemodynamics response to electrical stimulation could reflect a neural-vascular coupling of the spinal cord. Response in the dorsal areas to epidural stimulation was significantly higher and faster compared to the response in ventral spinal cord. Positive relation between the hemodynamics and the EMG responses was observed at the lower frequencies of epidural stimulation (20 and 40 Hz), which according to our previous findings can facilitate spinal circuitry after spinal cord injury, compared to higher frequencies (200 and 500 Hz). These findings suggest that different mechanisms could be involved in spinal cord hemodynamics changes during different parameters of electrical stimulation and for the first time provide the evidence that neural-vascular coupling of the spinal cord circuitry could be related to specific organization of spinal cord vasculature and hemodynamics.
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影响因子：
2
作者：
Guiho, Thomas;Delleci, Claire;Bauchet, Luc
通讯作者：
Bauchet, Luc
影响因子：
--
作者：
Gerasimenko, Yu P;Avelev, V D;Lavrov, I A
通讯作者：
Lavrov, I A
影响因子：
8.9
作者：
Grahn, Peter J.;Lavrov, Igor A.;Lee, Kendall H.
通讯作者：
Lee, Kendall H.
影响因子：
5.3
作者：
Capogrosso, Marco;Wenger, Nikolaus;Micera, Silvestro
通讯作者：
Micera, Silvestro
影响因子：
3
作者：
Gerasimenko, Yury P.;Lavrov, Igor A.;Edgerton, V. Reggie
通讯作者：
Edgerton, V. Reggie