Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
复制标题
蛋白质三级结构对乳腺转基因表达的影响是否比组织特异性密码子的使用更大?
DOI:
10.1007/s11248-010-9411-8
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发表时间:
2010-08
影响因子:
3
通讯作者:
Chen Y
中科院分区:
文献类型:
--
作者:
He Z;Zhao Y;Mei G;Li N;Chen Y
Animal mammary glands have been successfully employed to produce therapeutic recombinant human proteins. However, considerable variation in animal mammary transgene expression efficiency has been reported. We now consider whether aspects of codon usage and/or protein tertiary structure underlie this variation in mammary transgene expression.
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DOI:
10.1038/nbt0991-835
发表时间:
1991-09-01
期刊:
BIO-TECHNOLOGY
影响因子:
--
作者:
EBERT, KM;SELGRATH, JP;GORDON, K
通讯作者:
GORDON, K
影响因子:
3.5
作者:
Coulibaly, S;Besenfelder, U;Brem, G
通讯作者:
Brem, G
影响因子:
3.5
作者:
Bijvoet, AGA;Van Hirtum, H;Reuser, AJJ
通讯作者:
Reuser, AJJ
DOI:
10.1038/nbt0794-699
发表时间:
1994-07-01
期刊:
BIO-TECHNOLOGY
影响因子:
--
作者:
EBERT, KM;DITULLIO, P;ROBERTS, B
通讯作者:
ROBERTS, B
影响因子:
7.4
作者:
He, Zuyong;Yu, Shengli;Li, Ning
通讯作者:
Li, Ning