Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder: a randomized controlled trial
Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder: a randomized controlled trial
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经颅交流电刺激治疗重度抑郁症的方案：一项随机对照试验
DOI：
10.1097/cm9.0000000000000589
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发表时间：
2019-12
影响因子：
6.1
通讯作者：
Weijun Din
中科院分区：
文献类型：
--
作者：
Hongxing Wang;Kun Wang;Wenrui Zhang;Wenfeng Zhao;Xiaotong Yang;Li Wang;Mao Peng;Zhichao Sun;Qing Xue;Yu Jia;Ning Li;Kai Dong;Qian Zhang;Shuqin Zhan;Baoquan Min;Chunqiu Fan;Aihong Zhou;Haiqing Song;Lu Yin;Tianmei Si;Jing Huang;Jie Lu;Haixia Leng;Weijun Din
Abstract Background: Transcranial alternating current stimulation (tACS) offers a new approach for adult patients with major depressive disorder (MDD). The study is to evaluate the efficacy and safety of tACS treating MDD. Methods: This is an 8-week, double-blind, randomized, placebo-controlled study. Ninety-two drug-naive patients with MDD aged 18 to 65 years will receive 20 daily 40-min, 77.5-Hz, 15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks (week 4), following a 4-week observation period (week 8). The primary outcome is the remission rate defined as the 17-item Hamilton depression rating scale (HDRS-17) score ≤7 at week 8. Secondary outcomes are the rates of response at weeks 4 and 8 and rate of remission at week 4 based on HDRS-17, the proportion of participants having improvement in the clinical global impression-improvement, the change in HDRS-17 score (range, 0–52, with higher scores indicating more depression) over the study, and variations of brain imaging and neurocognition from baseline to week 4. Safety will be assessed by vital signs at weeks 4 and 8, and adverse events will be collected during the entire study. Discussion: The tACS applied in this trial may have treatment effects on MDD with minimal side effects. Trial registration: Chinese Clinical Trial Registry, ChiCTR1800016479; http://www.chictr.org.cn/showproj.aspx?proj=22048.
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影响因子：
7.7
作者：
Vossen, Alexandra;Gross, Joachim;Thut, Gregor
通讯作者：
Thut, Gregor
影响因子：
16.6
作者：
Lafon B;Henin S;Huang Y;Friedman D;Melloni L;Thesen T;Doyle W;Buzsáki G;Devinsky O;Parra LC;A Liu A
通讯作者：
A Liu A
影响因子：
1.7
作者：
Matsumoto H;Ugawa Y
通讯作者：
Ugawa Y
DOI：
--
发表时间：
2008
期刊：
Chinese mental health journal
影响因子：
--
作者：
Z. Bao
通讯作者：
Z. Bao
DOI：
10.4088/jcp.11m07413
发表时间：
2012-04-01
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Connolly, K Ryan;Helmer, Amanda;O'Reardon, John P
通讯作者：
O'Reardon, John P