White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile.
White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile.
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DOI：
10.1186/s13229-020-00379-6
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发表时间：
2020-10-19
期刊：
影响因子：
6.2
通讯作者：
Hashimoto RI
中科院分区：
文献类型：
--
作者：
Ohta H;Aoki YY;Itahashi T;Kanai C;Fujino J;Nakamura M;Kato N;Hashimoto RI
自闭症谱系障碍(ASD)和注意力缺陷/多动障碍(ADHD)具有很高的共现率，并具有包括感觉症状在内的非典型行为特征。目前的弥散张量成像(DTI)研究是为了检查是否以及如何在患有发育障碍(DD)的成年人群中观察到脑白质的变化，并确定ASD和ADHD之间的大脑感觉关系是如何共享的或不同的。我们收集了患有先天性心脏病的成人人群(初步诊断为房间隔缺乏症：N = 105，注意缺陷多动障碍：N= 55)以及年龄和性别匹配的典型发展中(TD)参与者(n = 58)的DTI数据。使用基于轨迹的空间统计学方法分析体素方向的分数各向异性(FA)、平均扩散系数、轴向扩散系数和径向扩散系数(RD)。感觉症状的严重程度使用青少年/成人感觉简表(AASP)进行评估。分类分析发现，体素簇显示出DD对胼胝体后部及其在右侧大脑半球的延伸的FA和RD有显著影响。此外，使用AASP评分的回归分析显示，在大部分受影响的胼胝体区域，FA或RD与感觉症状程度的关系的斜率在两个DDD之间是平行的。在ASD和ADHD中，确实存在一个小但有意义的集群，表明AASP子量表评分与RD之间的关联存在差异。参与者的年龄范围可能过于简单化。这些结果表明，ASD和ADHD的白质改变及其与感觉症状的关系在很大程度上是相同的，在DD中，局部性异常显示出诊断之间的显著差异。
Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have high rates of co-occurrence and share atypical behavioral characteristics, including sensory symptoms. The present diffusion tensor imaging (DTI) study was conducted to examine whether and how white matter alterations are observed in adult populations with developmental disorders (DD) and to determine how brain–sensory relationships are either shared between or distinct to ASD and ADHD. We collected DTI data from adult population with DD (a primary diagnosis of ASD: n = 105, ADHD: n = 55) as well as age- and sex-matched typically developing (TD) participants (n = 58). Voxel-wise fractional anisotropy (FA), mean diffusivity, axial diffusivity, and radial diffusivity (RD) were analyzed using tract-based spatial statistics. The severities of sensory symptoms were assessed using the Adolescent/Adult Sensory Profile (AASP). Categorical analyses identified voxel clusters showing significant effects of DD on FA and RD in the posterior portion of the corpus callosum and its extension in the right hemisphere. Furthermore, regression analyses using the AASP scores revealed that slopes in relationships of FA or RD with the degree of sensory symptoms were parallel between the two DDs in large parts of the affected corpus callosum regions. A small but significant cluster did exist showing difference in association between an AASP subscale score and RD across ASD and ADHD. Wide age range of the participants may be oversimplified. These results indicate that white matter alteration and their relationships to sensory symptoms are largely shared between ASD and ADHD, with localized abnormalities showing significant between-diagnosis differences within DD.
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影响因子：
4.8
作者：
Floris DL;Lai MC;Auer T;Lombardo MV;Ecker C;Chakrabarti B;Wheelwright SJ;Bullmore ET;Murphy DG;Baron-Cohen S;Suckling J
通讯作者：
Suckling J
影响因子：
25.8
作者：
Aoki, Yuta;Yoncheva, Yuliya N.;Di Martino, Adriana
通讯作者：
Di Martino, Adriana
影响因子：
2.4
作者：
Demopoulos, Carly;Arroyo, Monica S.;Marco, Elysa
通讯作者：
Marco, Elysa
影响因子：
7.6
作者：
Chen, Qi;Brikell, Isabell;Larsson, Henrik
通讯作者：
Larsson, Henrik
DOI：
10.15585/mmwr.ss6706a1
发表时间：
2018-04-27
期刊：
Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002)
影响因子：
--
作者：
Baio J;Wiggins L;Christensen DL;Maenner MJ;Daniels J;Warren Z;Kurzius-Spencer M;Zahorodny W;Robinson Rosenberg C;White T;Durkin MS;Imm P;Nikolaou L;Yeargin-Allsopp M;Lee LC;Harrington R;Lopez M;Fitzgerald RT;Hewitt A;Pettygrove S;Constantino JN;Vehorn A;Shenouda J;Hall-Lande J;Van Naarden Braun K;Dowling NF
通讯作者：
Dowling NF