Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.
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流体外B细胞反应与COVID-19的中和抗体和发病率相关。
DOI：
10.1038/s41590-020-00814-z
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发表时间：
2020-12
影响因子：
30.5
通讯作者：
Sanz I
中科院分区：
文献类型：
--
作者：
Woodruff MC;Ramonell RP;Nguyen DC;Cashman KS;Saini AS;Haddad NS;Ley AM;Kyu S;Howell JC;Ozturk T;Lee S;Suryadevara N;Case JB;Bugrovsky R;Chen W;Estrada J;Morrison-Porter A;Derrico A;Anam FA;Sharma M;Wu HM;Le SN;Jenks SA;Tipton CM;Staitieh B;Daiss JL;Ghosn E;Diamond MS;Carnahan RH;Crowe JE Jr;Hu WT;Lee FE;Sanz I
A wide spectrum of clinical manifestations has become a hallmark of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although the immunological underpinnings of diverse disease outcomes remain to be defined. We performed detailed characterization of B cell responses through high-dimensional flow cytometry to reveal substantial heterogeneity in both effector and immature populations. More notably, critically ill patients displayed hallmarks of extrafollicular B cell activation and shared B cell repertoire features previously described in autoimmune settings. Extrafollicular activation correlated strongly with large antibody-secreting cell expansion and early production of high concentrations of SARS-CoV-2-specific neutralizing antibodies. Yet, these patients had severe disease with elevated inflammatory biomarkers, multiorgan failure and death. Overall, these findings strongly suggest a pathogenic role for immune activation in subsets of patients with COVID-19. Our study provides further evidence that targeted immunomodulatory therapy may be beneficial in specific patient subpopulations and can be informed by careful immune profiling.
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影响因子：
46.9
作者：
Becht, Etienne;McInnes, Leland;Newell, Evan W.
通讯作者：
Newell, Evan W.
影响因子：
30.5
作者：
Manni M;Gupta S;Ricker E;Chinenov Y;Park SH;Shi M;Pannellini T;Jessberger R;Ivashkiv LB;Pernis AB
通讯作者：
Pernis AB
DOI：
10.1084/jem.189.10.1639
发表时间：
1999-05-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan OT;Hannum LG;Haberman AM;Madaio MP;Shlomchik MJ
通讯作者：
Shlomchik MJ
DOI：
10.1109/tkde.2020.3004939
发表时间：
2022-05-01
影响因子：
8.9
作者：
Liu, Lu;Zhou, Tianyi;Zhang, Chengqi
通讯作者：
Zhang, Chengqi
登革热病毒感染诱导CD14（+）CD16（+）单核细胞种群的扩展，从而刺激了浆膜分化。
影响因子：
30.3
作者：
Kwissa M;Nakaya HI;Onlamoon N;Wrammert J;Villinger F;Perng GC;Yoksan S;Pattanapanyasat K;Chokephaibulkit K;Ahmed R;Pulendran B
通讯作者：
Pulendran B