A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract.
A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract.
复制标题
关于胃肠道中石榴的抗炎活性的综述。
DOI：
10.1155/2013/247145
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Dell'agli M
中科院分区：
文献类型：
--
作者：
Colombo E;Sangiovanni E;Dell'agli M
石榴的几种生物活性在文献中已被广泛描述，但迄今为止尚未综述其在胃肠道中的抗炎作用。本论文的目的是总结证据支持或反对石榴的功效，以应对胃肠道的炎症条件。本文分为三个部分：（1）第一部分致力于石榴活性化合物在胃肠道中的修饰;（2）第二部分考虑有关石榴在胃水平的抗炎作用的文献;（3）第三部分考虑石榴在肠道中的抗炎作用。对整个水果或果汁、果皮和花进行的体内研究表明，在各种动物模型中具有抗溃疡作用。鞣花酸是主要负责这种效果，虽然其他个别鞣花单宁可能有助于混合物的生物活性。石榴的不同制剂，包括果皮，花，种子和果汁的提取物，在肠道中显示出显着的抗炎活性。没有发现临床研究，因此表明未来的临床研究是必要的，以澄清石榴在胃肠道中的有益作用。
Several biological activities of pomegranate have been widely described in the literature, but the anti-inflammatory effect in the gastrointestinal tract has not been reviewed till now. The aim of the present paper is to summarize the evidence for or against the efficacy of pomegranate for coping with inflammatory conditions of the gastro-intestinal tract. The paper has been organized in three parts: (1) the first one is devoted to the modifications of pomegranate active compounds in the gastro-intestinal tract; (2) the second one considering the literature regarding the anti-inflammatory effect of pomegranate at gastric level; (3) the third part considers the anti-inflammatory effect of pomegranate in the gut. In vivo studies performed on the whole fruit or juice, peel, and flowers demonstrate antiulcer effect in a variety of animal models. Ellagic acid was the main responsible for this effect, although other individual ellagitannins could contribute to the biological activity of the mixture. Different preparations of pomegranate, including extracts from peels, flowers, seeds, and juice, show a significant anti-inflammatory activity in the gut. No clinical studies have been found, thus suggesting that future clinical studies are necessary to clarify the beneficial effects of pomegranate in the gastrointestinal tract.
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影响因子：
4.4
作者：
Caruso, Roberta;Fina, Daniele;Monteleone, Giovanni
通讯作者：
Monteleone, Giovanni
DOI：
10.1152/ajpgi.00248.2012
发表时间：
2012-09-01
影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
3.2
作者：
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