Expression of cadherins and catenins in oral epithelial dysplasia and squamous cell carcinoma.
Expression of cadherins and catenins in oral epithelial dysplasia and squamous cell carcinoma.
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钙粘蛋白和连环蛋白在口腔上皮发育不良和鳞状细胞癌中的表达。
DOI：
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发表时间：
2007
影响因子：
3.3
通讯作者：
A. M. Brown
中科院分区：
文献类型：
--
作者：
H. K. Williams;D. Sanders;J. Jankowski;G. Landini;A. M. Brown
通过比较钙粘蛋白和连环蛋白在正常和不典型增生上皮与原发癌和转移癌中的表达，检测了口腔癌发生过程中钙粘蛋白和连环蛋白的免疫细胞化学表达。而对照上皮细胞显示正常分布的P和E钙粘蛋白和连环蛋白，在严重发育不良的P-钙粘蛋白上调。在其他情况下，在原位癌浸润癌附近，钙粘蛋白和连环蛋白的膜表达减少或丢失。E-cadherin和catenins表达的变化表明E-cadherin/catenin复合物的破坏是与侵袭相关的晚期事件。在原发性癌细胞中，钙粘蛋白和连环蛋白的细胞膜和细胞质染色减少。在分化较好的癌中，上皮钙粘蛋白的异常定位发生在更浅表的部分，提示上皮钙粘蛋白复合物异常。相反，在原发癌的深浸润边缘和大多数低分化癌中，钙粘蛋白和连环蛋白的膜表达减少或消失。至少对于E-cadherin，这种减少似乎与分化、侵袭和可能的预后相关。钙粘蛋白和相关的连环蛋白的表达变化的可能机制和进一步研究的领域进行了讨论。
The immunocytochemical expression of cadherins and catenins was examined during the process of oral carcinogenesis by comparing their expression in normal and dysplastic epithelium with primary and metastatic carcinomas. While control epithelium showed normal distribution for P and E cadherin and the catenins, in severe dysplasia P-cadherin was upregulated. In other cases and in carcinoma-in-situ adjacent to infiltrating carcinomas, membranous expression of the cadherins and catenins was reduced or lost. The changes in expression of E-cadherin and the catenins suggest that disruption of the E-cadherin/catenin complex is a late event associated with invasion. In primary carcinomas reduced membranous and cytoplasmic staining were observed for both cadherins and catenins. Abnormal localisation of E-cadherin occurred in the more superficial parts of the better differentiated carcinomas, suggesting abnormality to the E-cadherin complex(es). In contrast, membranous expression of cadherins and catenins was reduced or lost in the deep invasive margin of primary carcinomas and in most poorly differentiated carcinomas. For E-cadherin at least, this reduction appears associated with differentiation, invasion and possibly prognosis. Possible mechanisms involved for changes in expression of the cadherins and associated catenins and areas for further study are discussed.
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影响因子：
4.6
作者：
G. Levi;B. Gumbiner;J. Thiery
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
HARRIS, CC
影响因子：
11.2
作者：
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