Dairy intake during adolescence and risk of colorectal adenoma later in life.
Dairy intake during adolescence and risk of colorectal adenoma later in life.
复制标题
青春期的乳制品摄入量与晚年患结直肠腺瘤的风险。
DOI：
10.1038/s41416-020-01203-x
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发表时间：
2021-03
影响因子：
8.8
通讯作者：
Wu K
中科院分区：
文献类型：
--
作者：
Nimptsch K;Lee DH;Zhang X;Song M;Farvid MS;Rezende LFM;Cao Y;Chan AT;Fuchs C;Meyerhardt J;Nowak JA;Willett WC;Ogino S;Giovannucci E;Pischon T;Wu K
成年期较高的乳制品摄入量与较低的结直肠癌风险有关。由于结直肠癌的发生跨越几十年，我们假设青春期摄入更多的乳制品与结直肠腺瘤（结直肠癌的前体）的风险降低有关。在来自护士健康研究2的27，196名女性中，招募时年龄为25-42岁（1989年），他们在1998年完成了经验证的高中饮食问卷，并在1998年至2011年期间接受了至少一次下肠道内窥镜检查，使用聚类数据的logistic回归计算比值比（OR）和95%置信区间（CI）。在2239名妇女中诊断出结直肠腺瘤。青春期乳制品消费与结直肠腺瘤风险无关（OR最高vs.最低[≥4 vs. ≤1.42份/天]五分位数[95% CI] 0.94 [0.80，1.11]）。根据解剖部位，青少年乳制品摄入量较高与直肠腺瘤风险较低相关（0.63 [0.42，0.95]），但与近端（1.01 [0.80，1.28]）或远端（0.97 [0.76，1.24]）结肠腺瘤风险无关。观察到与组织学晚期（0.72 [0.51，1.00]）而非晚期（1.07 [0.86，1.33]）腺瘤呈负相关。在这个年轻女性的大型队列中，青少年乳制品摄入量较高与生活后期直肠和晚期腺瘤风险较低相关。
Higher dairy intake during adulthood has been associated with lower colorectal cancer risk. As colorectal carcinogenesis spans several decades, we hypothesised that higher dairy intake during adolescence is associated with lower risk of colorectal adenoma, a colorectal cancer precursor. In 27,196 females from the Nurses’ Health Study 2, aged 25–42 years at recruitment (1989), who had completed a validated high school diet questionnaire in 1998 and undergone at least one lower bowel endoscopy between 1998 and 2011, logistic regression for clustered data was used to calculate odds ratios (ORs) and 95% confidence intervals (CI). Colorectal adenomas were diagnosed in 2239 women. Dairy consumption during adolescence was not associated with colorectal adenoma risk (OR highest vs. lowest [≥4 vs. ≤1.42 servings/day] quintile [95% CI] 0.94 [0.80, 1.11]). By anatomical site, higher adolescent dairy intake was associated with lower rectal (0.63 [0.42, 0.95]), but not proximal (1.01 [0.80, 1.28]) or distal (0.97 [0.76, 1.24]) colon adenoma risk. An inverse association was observed with histologically advanced (0.72 [0.51, 1.00]) but not non-advanced (1.07 [0.86, 1.33]) adenoma. In this large cohort of younger women, higher adolescent dairy intake was associated with lower rectal and advanced adenoma risk later in life.
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结直肠癌危险因素与锯齿状息肉和传统腺瘤风险之间的关联。
影响因子：
29.4
作者：
He X;Wu K;Ogino S;Giovannucci EL;Chan AT;Song M
通讯作者：
Song M
影响因子：
6.4
作者：
Keum, NaNa;Lee, Dong Hoon;Giovannucci, Edward L.
通讯作者：
Giovannucci, Edward L.
影响因子：
8.8
作者：
Cao, Y.;Keum, N. N.;Chan, A. T.;Fuchs, C. S.;Wu, K.;Giovannucci, E. L.
通讯作者：
Giovannucci, E. L.
DOI：
10.1016/j.bbamcr.2015.02.011
发表时间：
2015-09
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Aggarwal A;Prinz-Wohlgenannt M;Tennakoon S;Höbaus J;Boudot C;Mentaverri R;Brown EM;Baumgartner-Parzer S;Kállay E
通讯作者：
Kállay E
DOI：
10.1158/1940-6207.capr-12-0292
发表时间：
2012-10
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Ahearn TU;Shaukat A;Flanders WD;Rutherford RE;Bostick RM
通讯作者：
Bostick RM