miR-27b-3p inhibits proliferation and potentially reverses multi-chemoresistance by targeting CBLB/GRB2 in breast cancer cells.
miR-27b-3p inhibits proliferation and potentially reverses multi-chemoresistance by targeting CBLB/GRB2 in breast cancer cells.
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miR-27b-3p 通过靶向乳腺癌细胞中的 CBLB/GRB2 抑制增殖并可能逆转多重化疗耐药性
DOI：
10.1038/s41419-017-0211-4
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发表时间：
2018-02-07
影响因子：
9
通讯作者：
Fan W
中科院分区：
文献类型：
--
作者：
Chen D;Si W;Shen J;Du C;Lou W;Bao C;Zheng H;Pan J;Zhong G;Xu L;Fu P;Fan W
耐药仍然是传统化疗药物治疗乳腺癌的一个主要问题。由于化疗耐药机制的异质性和复杂性，大多数专注于单一途径的努力都是不成功的，探索新的个性化治疗方法变得迫切。通过系统方法，我们发现microRNA-27b-3p （miR-27b）是乳腺癌组织和细胞系中缺失的一种miRNA，在使乳腺癌细胞对体外和体内广泛的抗癌药物敏感方面起着重要作用。机制分析表明，miR-27b通过直接靶向CBLB和GRB2使PI3K/Akt和MAPK/Erk信号通路失活，从而增强对PTX的应答。此外，miR-27b被认为是乳腺癌患者化疗耐药、临床病理特征和预后中有前景的分子生物标志物。总之，我们提出联合使用miR-27b和化疗药物可能是一种有希望的治疗策略，可以增加乳腺癌的长期药物反应。
Drug resistance remains a major problem in the treatment of conventional chemotherapeutic agents in breast cancers. Owing to heterogeneity and complexity of chemoresistance mechanisms, most efforts that focus on a single pathway were unsuccessful, and exploring novel personalized therapeutics becomes urgent. By a system approach, we identified that microRNA-27b-3p (miR-27b), a miRNA deleted in breast cancer tissues and cell lines, has a master role in sensitizing breast cancer cells to a broad spectrum of anticancer drugsin vitroandin vivo. Mechanistic analysis indicated that miR-27b enhanced responses to PTX by directly targeting CBLB and GRB2 to inactivate both PI3K/Akt and MAPK/Erk signaling pathways. Further, miR-27b was identified as a promising molecular biomarker in chemoresistance, clinicopathological features, and prognosis for breast cancer patients. In conclusion, we propose that combinational use of miR-27b and chemotherapeutic agents might be a promising therapeutic strategy to increase long-term drug responses in breast cancers.
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影响因子：
16.6
作者：
Takahashi, Ryou-u;Miyazaki, Hiroaki;Takeshita, Fumitaka;Yamamoto, Yusuke;Minoura, Kaho;Ono, Makiko;Kodaira, Makoto;Tamura, Kenji;Mori, Masaki;Ochiya, Takahiro
通讯作者：
Ochiya, Takahiro
影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
microRNA表达模式在人肝内胆管癌中的作用。
影响因子：
25.7
作者：
Chen, Lei;Yan, He-Xin;Wang, Hong-Yang
通讯作者：
Wang, Hong-Yang
影响因子：
50.3
作者：
Garofalo M;Di Leva G;Romano G;Nuovo G;Suh SS;Ngankeu A;Taccioli C;Pichiorri F;Alder H;Secchiero P;Gasparini P;Gonelli A;Costinean S;Acunzo M;Condorelli G;Croce CM
通讯作者：
Croce CM
影响因子：
--
作者：
Hydbring, Per;Badalian-Very, Gayane
通讯作者：
Badalian-Very, Gayane