Diet and exercise changes following bone densitometry in the Patient Activation After DXA Result Notification (PAADRN) study.
Diet and exercise changes following bone densitometry in the Patient Activation After DXA Result Notification (PAADRN) study.
复制标题
在 DXA 结果通知后患者激活 (PAADRN) 研究中，骨密度测量后饮食和运动的变化。
DOI：
10.1007/s11657-017-0402-8
复制
发表时间：
2018
影响因子：
3
通讯作者：
PAADRNInvestigators
中科院分区：
文献类型：
--
作者：
Roblin,DouglasW;Cram,Peter;Lou,Yiyue;Edmonds,StephanieW;Hall,SylvieF;Jones,MichaelP;Saag,KennethG;Wright,NicoleC;Wolinsky,FredricD;PAADRNInvestigators
在老年人中，钙和维生素D的摄入量和运动是不理想的。在骨密度测量之后，在52周的时间里，一封传达个性化骨折风险的信件和一本教育小册子改善了参与者的生活方式，但没有比现有的沟通策略更有效。简单的沟通策略不足以达到最佳水平的骨骼健康行为。目的：DXA结果通知后的患者激活（PAADRN）研究旨在评估在DXA后不久向患者邮寄具有个体化骨折风险的信件和教育小册子是否可以改善骨骼健康行为（每日钙摄入量，维生素D补充和每周锻炼），而不是像常规护理那样缓慢，个性化沟通较少。方法在三个地点招募年龄≥50岁的受试者，在他们的DXA后，按1:1的比例随机分配到干预组和对照组（仅常规护理）。数据收集于入组后第12周和第52周的访谈和电话调查。意向治疗分析对20,397名符合条件的参与者中的7749人进行了分析。比较了研究组内部和研究组之间骨骼健康行为的变化。用多变量线性和逻辑回归模型估计平均治疗效果和治疗效果的异质性。结果在未经调整的分析中，干预组和对照组的钙摄入量、维生素D补充量和每周锻炼次数在52周内显著增加（均p< 0.001）。在未调整分析和多变量模型中，每种行为的增加在干预组和对照组之间没有显著差异。然而，与其他研究参与者相比，干预组10年骨折风险为20%的参与者的钙摄入量明显增加（p= 0.031）。结论：在DXA后的52周内，所有参与者的骨骼健康行为均有所改善。与常规护理相比，收到PAADRN信件和教育手册并没有直接改善骨骼健康行为。试验注册DXA结果通知后患者激活（PAADRN）研究已在ClinicalTrials注册。网址：NCT01507662， https://clinicaltrials.gov/ct2/show/NCT01507662
SummaryCalcium and vitamin D intake and exercise are suboptimal among older adults. Following bone densitometry, a letter communicating individualized fracture risk accompanied by an educational brochure improved participants’ lifestyle—but no more than existing communication strategies—over 52 weeks. Simple communication strategies are insufficient for achieving optimal levels of bone health behaviors.PurposeThe Patient Activation After DXA Result Notification (PAADRN) study was designed to evaluate whether a letter with individualized fracture risk and an educational brochure mailed to patients soon after their DXA might improve bone health behaviors (daily calcium intake, vitamin D supplementation, and weekly exercise sessions) compared to slower, less individualized communication characterizing usual care.MethodsParticipants ≥ 50 years were recruited, at three sites, following their DXA and randomized with 1:1 allocation to intervention and control (usual care only) groups. Data were collected at enrollment interview and by phone survey at 12 and 52 weeks thereafter. Intention-to-treat analyses were conducted on 7749 of the 20,397 eligible participants who enrolled. Changes in bone health behaviors were compared within and between study groups. Average treatment effects and heterogeneity of treatment effects were estimated with multivariable linear and logistic regression models.ResultsIn unadjusted analyses, calcium intake, vitamin D supplementation, and weekly exercise sessions increased significantly over 52 weeks within both the intervention and control groups (allp< 0.001). In unadjusted analyses and multivariable models, increases in each behavior did not significantly differ between the intervention and control groups. Intervention group participants with a > 20% 10-year fracture risk at enrollment did, however, have a significantly greater increase in calcium intake compared to other study participants (p= 0.031).ConclusionsBone health behaviors improved, on average, over 52 weeks among all participants following a DXA. Receipt of the PAADRN letter and educational brochure did not directly improve bone health behaviors compared to usual care.Trial registrationThe Patient Activation after DXA Result Notification (PAADRN) Study is registered at ClinicalTrials.Gov: NCT01507662, https://clinicaltrials.gov/ct2/show/NCT01507662
登录
查看更多内容
HNK-1 (Leu-7) 人淋巴细胞的表征。
DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Abo,T;Cooper,MD;Balch,CM
通讯作者：
Balch,CM
影响因子：
56.9
作者：
KUNG, PC;GOLDSTEIN, G;SCHLOSSMAN, SF
通讯作者：
SCHLOSSMAN, SF
由免疫球蛋白特异性受体定义的人类 T 细胞亚群的特征。
DOI：
10.1007/978-1-4684-0922-2_2
发表时间：
1978
期刊：
Contemporary topics in immunobiology
影响因子：
--
作者：
L. Moretta;Manlio Ferrarini;Max D. Cooper
通讯作者：
Max D. Cooper
慢性淋巴细胞白血病的免疫学研究。-I。
DOI：
--
发表时间：
1981
期刊：
Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis
影响因子：
--
作者：
P. Hokland;J. Ellegaard
通讯作者：
J. Ellegaard
B 细胞慢性淋巴细胞白血病患者的异常 T 淋巴细胞亚群：单克隆抗体分析。
影响因子：
4.4
作者：
C. Platsoucas;M. Galinski;S. Kempin;L. Reich;B. Clarkson;R. Good
通讯作者：
R. Good