Phase advances of circadian rhythms in somatostatin depleted rats: effects of cysteamine on rhythms of locomotor activity and electrical discharge of the suprachiasmatic nucleus
Phase advances of circadian rhythms in somatostatin depleted rats: effects of cysteamine on rhythms of locomotor activity and electrical discharge of the suprachiasmatic nucleus
复制标题
生长抑素耗尽大鼠昼夜节律的阶段性进展：半胱胺对运动活动节律和视交叉上核放电的影响
DOI：
--
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
S. Watanabe
中科院分区：
文献类型：
--
作者：
C. Fukuhara;S. Inouye;K. Aoki;T. Hamada;S. Shibata;S. Watanabe
生长抑素在哺乳动物的昼夜节律起搏器视交叉上核（SCN）中合成。为了探讨生长抑素在昼夜节律系统中的功能意义，我们研究了大鼠运动活动的节律和SCN神经元的电放电率在SCN生长抑素水平暂时耗尽后的脑片。腹腔注射生长抑素耗竭剂半胱胺（200 mg/kg）可显著降低SCN内生长抑素水平，并维持低水平3 ~ 4 d。另一方面，这种给药在大鼠随后的自主活动的自由奔跑节律中诱导了约51分钟的显著相位提前。在冠状下丘脑切片中给予半胱胺后，还观察到SCN中放电率的昼夜节律的显著相位提前。这些持续的相移后，管理的生长抑素耗尽剂可能表明，生长抑素的变化在SCN的昼夜节律起搏器的反馈影响。
Somatostatin is synthesized in the suprachiasmatic nucleus (SCN), a circadian pacemaker in mammals. To explore the functional significance of somatostatin in the circadian system, we examined rhythms of rat locomotor activity and electrical firing rate of SCN neurons in the brain slice after temporal depletion of somatostatin levels in the SCN. Intraperitoneal administration of cysteamine (200 mg/kg), a somatostatin depletor, significantly reduced somatostatin level in the in vivo SCN 5 min after injection and kept low level as long as 3 to 4 days. This administration, on the other hand, induced significant phase advances of about 51 min in the subsequent free-running rhythm of locomotor activity of the rat. A marked phase advance in the circadian rhythm of firing rate in the SCN was also observed after administration of cysteamine in coronal hypothalamic slices. These persistent phase shifts after administration of a somatostatin depletor may suggest that the change of somatostatin level in the SCN have a feedback influence on the circadian pacemaker.
半胱胺：垂体催乳素的有效且特异性消耗剂。
DOI：
10.1126/science.7089575
发表时间：
1982
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Millard,WJ;Sagar,SM;Landis,DM;Martin,JB
通讯作者：
Martin,JB
给予半胱胺可耗尽大鼠组织中的生长抑素。
影响因子：
4.8
作者：
Szabo,S;Reichlin,S
通讯作者：
Reichlin,S
大鼠下丘脑视交叉上核：内在解剖学。
DOI：
10.1002/cne.901910410
发表时间：
1980
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
VandenPol,AN
通讯作者：
VandenPol,AN