Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases.
Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases.
复制标题
DOI：
10.1172/jci163838
复制
发表时间：
2023-01-03
影响因子：
15.9
通讯作者：
Ginsburg, David
中科院分区：
文献类型：
--
作者：
Tang, Vi T.;Ginsburg, David
大多数到达细胞外空间或各种细胞内区室的蛋白质必须通过细胞内分泌途径。第一步是通过由五种核心蛋白组成的外壳蛋白复合物II （COPII）将货物从内质网（ER）腔募集和运输到高尔基体。另外的内质网跨膜蛋白，帮助货物招募被称为货物受体。基因复制事件导致哺乳动物基因组中存在多种COPII类似物。在这里，我们回顾了每个COPII蛋白的功能，与每个类似蛋白相关的人类疾病，以及类似蛋白之间功能守恒的证据。我们还提供了关于哺乳动物中两个原型货物受体LMAN1和SURF4的当前知识的总结，以及它们在人类健康和疾病中的作用。
Most proteins destined for the extracellular space or various intracellular compartments must traverse the intracellular secretory pathway. The first step is the recruitment and transport of cargoes from the endoplasmic reticulum (ER) lumen to the Golgi apparatus by coat protein complex II (COPII), consisting of five core proteins. Additional ER transmembrane proteins that aid cargo recruitment are referred to as cargo receptors. Gene duplication events have resulted in multiple COPII paralogs present in the mammalian genome. Here, we review the functions of each COPII protein, human disorders associated with each paralog, and evidence for functional conservation between paralogs. We also provide a summary of current knowledge regarding two prototypical cargo receptors in mammals, LMAN1 and SURF4, and their roles in human health and disease.
影响因子：
4.4
作者：
Henricson A;Sonnhammer EL;Baillie DL;Gomes AV
通讯作者：
Gomes AV
DOI：
10.1083/jcb.30.1.97
发表时间：
1966-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Dallner G;Siekevitz P;Palade GE
通讯作者：
Palade GE