Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society.
Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society.
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难治性/难治性哮喘：需要采用综合方法来定义临床表型、评估危险因素、了解病理生理学并寻找新疗法。
DOI：
10.1034/j.1399-3003.1999.13e43.x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
P. Sterk
中科院分区：
文献类型：
--
作者：
P. Godard;E. Adelroth;Jon G Ayres;Neil Barnes;P. Barnes;E. H. Bel;P. Burney;P. Chanez;G. Connett;Christopher Corrigan;J. Blic;L.M. Fabbri;Guy Joos;H. Kerstjens;P. Leuenberger;Sheila A. McKenzie;H. Magnussen;D. Postma;M. Saetta;S. Salmerón;Michael Silverman;P. Sterk
1997年成立了一个由欧洲呼吸学会支持的工作组，以解决与难治性/难治性哮喘有关的主要问题。虽然与哮喘患者的大量数量相比，涉及的患者群体较小，但这些患者在时间和金钱方面消耗了相当大比例的医疗资源[1]。工作组面临的主要问题是如何定义“疑难哮喘”、如何评估疑难哮喘患者、疑难哮喘的病理生理机制以及现有的治疗方法。该工作组还致力于确定必要的研究领域，以更好地了解哮喘的病因和新的治疗方法。该工作队提出的文件是不同意见的共识，将成为进一步研究的基础。制定定义
A Task Force supported by the European Respiratory Society was set up in 1997 in order to address the major issues relevant to difficult/therapy-resistant asthma. Although the group of patients involved is small in comparison to the high numbers of patients with asthma, these patients consume a significant proportion of medical resources in terms of both time and money [1]. The major issues facing the Task Force were how to define "difficult asthma", how the patient with difficult asthma should be evaluated, the pathophysiological mechanisms underlying difficult asthma and the treatments available. The Task Force also concerned itself with defining the areas of research necessary to bring about a greater understanding of the causes of difficult asthma and novel treatments. The document resulting from this Task Force represents a consensus of different opinions, which will form the basis for further research. Formulating the definition
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影响因子：
3.3
作者：
Fredberg, JJ;Jones, KA;Sieck, GC
通讯作者：
Sieck, GC
DOI：
10.1164/ajrccm.156.3.9610046
发表时间：
1997-09-01
影响因子：
24.7
作者：
Wenzel, SE;Szefler, SJ;Martin, RJ
通讯作者：
Martin, RJ
影响因子：
14.2
作者：
BROIDE, DH;LOTZ, M;WASSERMAN, SI
通讯作者：
WASSERMAN, SI
雾化利多卡因对严重糖皮质激素依赖性哮喘的影响。
影响因子：
8.9
作者：
Hunt,LW;Swedlund,HA;Gleich,GJ
通讯作者：
Gleich,GJ
影响因子：
3.3
作者：
Lawrence B. Pliss;E. Ingenito;R. H. Ingram
通讯作者：
Lawrence B. Pliss;E. Ingenito;R. H. Ingram