Feasibility of in vivo multi-parametric quantitative magnetic resonance imaging of the healthy sciatic nerve with a unified signal readout protocol.
Feasibility of in vivo multi-parametric quantitative magnetic resonance imaging of the healthy sciatic nerve with a unified signal readout protocol.
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DOI：
10.1038/s41598-023-33618-w
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发表时间：
2023-04-21
影响因子：
4.6
通讯作者：
Yiannakas, Marios C.
中科院分区：
文献类型：
--
作者：
Boonsuth, Ratthaporn;Battiston, Marco;Grussu, Francesco;Samlidou, Christina Maria;Calvi, Alberto;Samson, Rebecca S.;Gandini Wheeler-Kingshott, Claudia A. M.;Yiannakas, Marios C.
多年来，磁共振神经成像（MRN）已成功用于研究周围神经系统（PNS），因为它可以早期检测和精确定位神经组织损伤。然而，研究表明，MRN与多参数定量磁共振成像（qMRI）方法相结合的可行性，它提供了更具体的信息相关的神经组织成分和微观结构组织，可以是非常宝贵的。将先前在中枢神经系统中验证的新兴qMRI方法转化为PNS提供了真实的潜力，以在患者体内阐明PNS过多病症中涉及的潜在病理生理机制。本研究的目的是评估MRN与qMRI相结合的可行性，以测量扩散，磁化传递和松弛特性的健康坐骨神经在体内使用一个统一的信号读出协议。报告了健康坐骨神经中多参数qMRI方案以及规范性qMRI测量的重现性。本文提出的研究结果为在未来影响PNS的病理条件的研究中实际实施联合MRN-qMRI铺平了道路。
Magnetic resonance neurography (MRN) has been used successfully over the years to investigate the peripheral nervous system (PNS) because it allows early detection and precise localisation of neural tissue damage. However, studies demonstrating the feasibility of combining MRN with multi-parametric quantitative magnetic resonance imaging (qMRI) methods, which provide more specific information related to nerve tissue composition and microstructural organisation, can be invaluable. The translation of emerging qMRI methods previously validated in the central nervous system to the PNS offers real potential to characterise in patients in vivo the underlying pathophysiological mechanisms involved in a plethora of conditions of the PNS. The aim of this study was to assess the feasibility of combining MRN with qMRI to measure diffusion, magnetisation transfer and relaxation properties of the healthy sciatic nerve in vivo using a unified signal readout protocol. The reproducibility of the multi-parametric qMRI protocol as well as normative qMRI measures in the healthy sciatic nerve are reported. The findings presented herein pave the way to the practical implementation of joint MRN-qMRI in future studies of pathological conditions affecting the PNS.
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影响因子：
3.5
作者：
Garyfallidis E;Brett M;Amirbekian B;Rokem A;van der Walt S;Descoteaux M;Nimmo-Smith I;Dipy Contributors
通讯作者：
Dipy Contributors
影响因子：
19.7
作者：
Foesleitner, Olivia;Sulaj, Alba;Schwarz, Daniel
通讯作者：
Schwarz, Daniel
影响因子：
--
作者：
Chen, Yongsheng;Haacke, E Mark;Li, Jun
通讯作者：
Li, Jun
影响因子：
9.9
作者：
Dortch, Richard D.;Dethrage, Lindsey M.;Li, Jun
通讯作者：
Li, Jun
定量磁共振成像在多发性硬化症中临床应用。
DOI：
10.1093/brain/awab029
发表时间：
2021-06-22
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Granziera C;Wuerfel J;Barkhof F;Calabrese M;De Stefano N;Enzinger C;Evangelou N;Filippi M;Geurts JJG;Reich DS;Rocca MA;Ropele S;Rovira À;Sati P;Toosy AT;Vrenken H;Gandini Wheeler-Kingshott CAM;Kappos L;MAGNIMS Study Group
通讯作者：
MAGNIMS Study Group