Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration.
Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration.
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DOI：
10.3892/etm.2014.1909
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发表时间：
2014-10
影响因子：
2.7
通讯作者：
Alhashimi F
中科院分区：
文献类型：
--
作者：
Khabour OF;Abu-Rumeh L;Al-Jarrah M;Jamous M;Alhashimi F
腰椎间盘退变（LDD）是一个广泛存在的公共健康问题，可导致残疾和丧失生产力。脂联素是一种由脂肪组织分泌的脂肪因子，已被证明参与软骨体内平衡。本研究研究了脂联素基因（ADIPOQ） rs266729（−11377C/G）和rs2241766 （45T/G）单核苷酸多态性（snp）与LDD之间的关系。此外，还检测了血浆脂联素水平与LDD的相关性。研究共招募了289名受试者，168名LDD患者和122名健康人。采用聚合酶链反应-限制性片段长度多态性对所有受试者rs266729和rs2241766 snp进行基因分型。采用ELISA技术测定循环脂联素蛋白水平。脂联素水平与LDD之间存在很强的相关性（P<0.01），与健康对照组相比，患者的脂联素水平较高。脂联素水平的增加不受性别的影响。然而，在LDD患者和健康对照者之间，两种被检测多态性的基因型分布或等位基因频率没有发现显著差异（P < 0.05）。总之，脂联素似乎在LDD患者中升高。ADIPOQ基因中的rs266729和rs2241766 snp与LDD无关。
Lumbar disc degeneration (LDD) is a widespread public health problem that may lead to disability and loss of productivity. Adiponectin is an adipokine secreted by adipose tissue and has been shown to be involved in cartilage homeostasis. In the present study, the association between the rs266729 (−11377C/G) and rs2241766 (45T/G) single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and LDD was investigated. In addition, the correlation between the plasma adiponectin level and LDD was examined. A total of 289 subjects, 168 patients with LDD and 122 healthy individuals, were recruited in the study. All subjects were genotyped for rs266729 and rs2241766 SNPs using polymerase chain reaction-restriction fragment length polymorphism. Circulating levels of adiponectin protein were measured using the ELISA technique. A strong association was found between adiponectin level and LDD (P<0.01), where high levels of adiponectin were found in patients compared with healthy controls. The increase in adiponectin level was not affected by gender. However, no significant differences were found in the genotype distribution or allelic frequency of the two examined polymorphisms between patients with LDD and healthy controls (P>0.05). In conclusion, adiponectin appears to be elevated in patients with LDD. The rs266729 and rs2241766 SNPs in the ADIPOQ gene are not associated with LDD.
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影响因子：
2.7
作者：
Al-Azzam SI;Alkhateeb AM;Alzoubi KH;Alzayadeen RN;Ababneh MA;Khabour OF
通讯作者：
Khabour OF
影响因子：
--
作者：
Klein-Wieringa, Inge R.;van der Linden, Michael P. M.;Ioan-Facsinay, Andreea
通讯作者：
Ioan-Facsinay, Andreea
影响因子：
0.6
作者：
Hashemi M;Hanafi Bojd H;Eskandari Nasab E;Bahari A;Hashemzehi NA;Shafieipour S;Narouie B;Taheri M;Ghavami S
通讯作者：
Ghavami S
影响因子：
4.9
作者：
Kang EH;Lee YJ;Kim TK;Chang CB;Chung JH;Shin K;Lee EY;Lee EB;Song YW
通讯作者：
Song YW
影响因子：
3.7
作者：
Lin WP;Wang XJ;Wang CR;Zhang LQ;Li N;Wang FS;Lin JH
通讯作者：
Lin JH