Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease.
Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease.
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DOI：
10.5812/hepatmon.9527
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发表时间：
2013-05
影响因子：
0.6
通讯作者：
Ghavami S
中科院分区：
文献类型：
--
作者：
Hashemi M;Hanafi Bojd H;Eskandari Nasab E;Bahari A;Hashemzehi NA;Shafieipour S;Narouie B;Taheri M;Ghavami S
遗传和环境因素对非酒精性脂肪性肝病（NAFLD）的发展很重要。脂联素是一种白色和棕色脂肪组织激素，在能量稳态调节中起重要作用。最近的研究表明脂联素可能通过过氧化物酶体增殖物激活受体γ（PPARγ）途径在非酒精性脂肪肝中发挥作用。本研究旨在探讨脂联素rs 1501299（276 G/T）和rs 266729（-11377C/G）基因多态性与NAFLD的关系。83例诊断为NAFLD的患者和93例健康受试者被纳入研究。Tetra ARMS-PCR检测单核苷酸多态性。NAFLD组与对照组rs 266729基因多态性差异有统计学意义（χ2 = 7.35，P = 0.025）。rs 266729多态性在共显性（CC vs. CG：OR = 2.18，95%CI = 1.16 - 4.12，P = 0.016）和显性（CC vs. CG/GG：OR = 2.31，95%CI = 1.25 - 4.27，P = 0.008）遗传模型中增加了NAFLD的风险。与C等位基因相比，G等位基因增加NAFLD的危险性（OR = 1.63，95% CI = 1.03 ~ 2.57，P = 0.037）。脂联素rs 1501299基因多态性在各组间差异无统计学意义（χ2 = 0.70，P = 0.697）。脂联素rs 266729多态性可能是NAFLD易感性的一个候选基因。需要更大规模的研究来证实这些在不同人群中的发现。
Genetic and environmental factors are important for the development of nonalcoholic fatty liver disease (NAFLD). Adiponectin is a white and brown adipose tissue hormone, and have been found to play essential roles in the regulation of energy homoeostasis. Recent reports have identified a possible role of adiponectin in NAFLD via PPARγ pathway. The present study was designed to find out the impact of adiponectin rs1501299 (276G/T) and rs266729 (-11377C/G) gene polymorphisms in NAFLD. Eighty-three patients with diagnosis of NAFLD, and 93 healthy subjects were included in the study. Tetra ARMS-PCR was designed to detect single nucleotide polymorphisms. A significant difference was found between NAFLD and control group regarding the rs266729 polymorphism (χ2 = 7.35, P = 0.025). The rs266729 polymorphism increased the risk of NAFLD in codominant (CC vs. CG: OR = 2.18, 95% CI = 1.16 - 4.12, P = 0.016) and dominant (CC vs. CG/GG: OR = 2.31, 95% CI = 1.25 - 4.27; P = 0.008) inheritance tested models. The G allele increased the risk of NAFLD (OR = 1.63, 95% CI = 1.03 - 2.57, P = 0.037) in comparison with C allele. No significant difference was found between the groups concerning adiponectin rs1501299 gene polymorphism (χ2 = 0.70, P = 0.697). adiponectin rs266729 polymorphism might be a candidate gene, which determines the susceptibility to NAFLD. Larger studies are necessary to confirm these findings in various populations.
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