Propelling the Pediatric HIV Therapeutic Agenda With Science, Innovation, and Collaboration.
Propelling the Pediatric HIV Therapeutic Agenda With Science, Innovation, and Collaboration.
复制标题
DOI：
10.1097/qai.0000000000001747
复制
发表时间：
2018-08-15
期刊：
影响因子：
--
通讯作者：
Brouwers P
中科院分区：
文献类型：
--
作者：
Abrams EJ;Ananworanich J;Archary M;Ngongondo M;Brouwers P
儿科治疗议程上的一些众所周知的障碍导致了新药物、配方、策略和方法的引入严重延误，以治疗感染艾滋病毒的婴儿、儿童和青少年。全球景观。作者将总结当前和新出现的举措，以加快儿科治疗议程，包括创新和科学发现的说明性案例研究，在诊断和治疗非常年轻的儿童感染艾滋病毒。快速的生理和发育变化所带来的挑战，以及复杂的监管和财政环境的艾滋病毒治疗的儿童的轨迹，阻碍了儿科艾滋病毒治疗研究。最近为加速这一议程所做的努力包括优先考虑药物和制剂、按体重范围定义剂量、应用创新的研究设计、协同整个研究网络的工作以实现共同目标，以及建立全球优先研究议程。一项关于诊断和有效治疗新生儿和婴儿的举措的案例研究将说明基础科学研究的关键作用以及研究设计和实施的新方法，这些方法为全球结束艾滋病的努力提供了信息。以基础科学为依据并通过创新和全球合作实现的儿科治疗议程对于实现无艾滋病的一代至关重要。
A number of well-described obstacles to the pediatric therapeutic agenda have resulted in substantial delays in the introduction of new medications, formulations, strategies, and approaches to treat infants, children, and adolescents living with HIV. Global landscape. The authors will provide a summary of current and emerging initiatives to accelerate the pediatric therapeutic agenda including illustrative case studies of innovations and scientific discovery in diagnosis and treatment of very young children with HIV infection. The challenges posed by rapid physiologic and developmental changes that characterize the trajectory of childhood as well as the complex regulatory and fiscal milieu of HIV therapeutics have hampered pediatric HIV therapeutic research. Recent efforts to accelerate this agenda include prioritizing agents and formulations, defining dosing by weight bands, applying innovative study designs, synergizing work across research networks to achieve common goals, and the establishment of a global prioritized research agenda. A case study of initiatives to diagnose and effectively treat newborns and infants will illustrate the critical role of basic science research and novel approaches to study design and implementation that are informing global efforts to end AIDS. A pediatric therapeutic agenda informed by basic science and achieved through innovation and global cooperation is essential to achieve an AIDS-free generation.
影响因子：
2.2
作者：
Ananworanich J;Bunupuradah T;Apornpong T;Kosalaraksa P;Hansudewechakul R;Kanjanavanit S;Ngampiyaskul C;Wongsawat J;Luesomboon W;Ngo-Giang-Huong N;Jaimulwong T;Kerr SJ;Brouwers P;Shearer WT;Puthanakit T;PREDICT Study Group
通讯作者：
PREDICT Study Group
影响因子：
7.8
作者：
Mooney M;McWeeney S;Sékaly RP
通讯作者：
Sékaly RP