Gap junction networks can generate both ripple-like and fast ripple-like oscillations.
Gap junction networks can generate both ripple-like and fast ripple-like oscillations.
复制标题
间隙连接网络可以同时产生类似纹波的和快速纹波的振荡。
DOI：
10.1111/ejn.12386
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Whittington MA
中科院分区：
文献类型：
--
作者：
Simon A;Traub RD;Vladimirov N;Jenkins A;Nicholson C;Whittaker RG;Schofield I;Clowry GJ;Cunningham MO;Whittington MA
快速波动(FR)是网络振荡，其定义各不相同，频率在>；150至>；250赫兹之间，其机制存在争议。FRS似乎表明皮质组织有引发癫痫的倾向。在这里，我们展示了在自发性癫痫人的皮质组织在体外高达400赫兹的场振荡，并提出了一个网络模型，可以解释FRS本身，以及它们与“普通”(较慢的)涟漪的关系。我们用具有电耦合轴突的锥体神经元模型进行了网络模拟。当轴突到轴突的动作电位传导可靠时，波纹(<；250 Hz)是有利的。波纹群的活动是周期性的，而单个轴突的放电是相对不同的。从波纹到FRS的转换发生在一个与另一个细胞耦合的细胞中发生异位尖峰，而另一个细胞本身又与其他细胞成倍耦合。然后，传播只能从一个方向开始，这是一种适合重返大气层的条件。由此产生的振荡为250赫兹，持续或中断，在单个轴突的发射中几乎没有抖动。FR模型的形态类似于人类癫痫切除组织中自发发生的FRS。在体外，FRs被缝隙连接阻滞剂抑制。我们的数据表明，一个给定的网络可以通过缝隙连接产生涟漪、FRS，或者两者都产生，并且FRS受到轴突缝隙连接簇的青睐。如果轴突缝隙连接确实发生在癫痫组织中，并且由连接蛋白26(最近被证明介导未成熟的新皮质锥体细胞之间的耦合)介导，那么这一预测是可检验的。
Fast ripples (FRs) are network oscillations, defined variously as having frequencies of > 150 to > 250 Hz, with a controversial mechanism. FRs appear to indicate a propensity of cortical tissue to originate seizures. Here, we demonstrate field oscillations, at up to 400 Hz, in spontaneously epileptic human cortical tissue in vitro, and present a network model that could explain FRs themselves, and their relation to ‘ordinary’ (slower) ripples. We performed network simulations with model pyramidal neurons, having axons electrically coupled. Ripples (< 250 Hz) were favored when conduction of action potentials, axon to axon, was reliable. Whereas ripple population activity was periodic, firing of individual axons varied in relative phase. A switch from ripples to FRs took place when an ectopic spike occurred in a cell coupled to another cell, itself multiply coupled to others. Propagation could then start in one direction only, a condition suitable for re-entry. The resulting oscillations were > 250 Hz, were sustained or interrupted, and had little jitter in the firing of individual axons. The form of model FR was similar to spontaneously occurring FRs in excised human epileptic tissue. In vitro, FRs were suppressed by a gap junction blocker. Our data suggest that a given network can produce ripples, FRs, or both, via gap junctions, and that FRs are favored by clusters of axonal gap junctions. If axonal gap junctions indeed occur in epileptic tissue, and are mediated by connexin 26 (recently shown to mediate coupling between immature neocortical pyramidal cells), then this prediction is testable.
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影响因子：
16.2
作者：
Maier, Nikolaus;Tejero-Cantero, Alvaro;Schmitz, Dietmar
通讯作者：
Schmitz, Dietmar
DOI：
10.1073/pnas.1103546108
发表时间：
2011-08-30
影响因子：
11.1
作者：
Baehner, Florian;Weiss, Elisa K.;Draguhn, Andreas
通讯作者：
Draguhn, Andreas
影响因子：
14.5
作者：
Jiruska, Premysl;Finnerty, Gerald T.;Jefferys, John G. R.
通讯作者：
Jefferys, John G. R.
DOI：
10.1073/pnas.0705281104
发表时间：
2007-07-24
影响因子：
11.1
作者：
Hamzei-Sichani, Farid;Kamasawa, Naomi;Traub, Roger D.
通讯作者：
Traub, Roger D.
影响因子：
2.5
作者：
Gansert, Juliane;Golowasch, Jorge;Nadim, Farzan
通讯作者：
Nadim, Farzan