Role of myelin-associated inhibitors in axonal repair after spinal cord injury.

Role of myelin-associated inhibitors in axonal repair after spinal cord injury.
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DOI:
10.1016/j.expneurol.2011.05.001
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发表时间:
2012-05
影响因子:
5.3
通讯作者:
Zheng, Binhai
Zheng, Binhai
中科院分区:
医学2区
文献类型:
--
作者:
Lee, Jae K.;Zheng, Binhai

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髓磷脂相关的轴突生长抑制剂,包括Nogo、MAG和OMgp,一直是研究的热点。无数的实验方法已被应用于研究靶向这些分子促进脊髓损伤后轴突修复的潜力。然而,关于它们在轴突再生中的作用仍然存在矛盾的结果,因此缺乏关于这些分子如何靶向促进轴突修复的内聚机制。一个主要原因可能是首先缺乏对轴突再生的明确定义。然而,最近来自小鼠遗传研究的数据表明,这些分子在中枢神经系统轴突修复中的作用可能比以前想象的更复杂。
Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research. A myriad of experimental approaches have been applied to investigate the potential of targeting these molecules to promote axonal repair after spinal cord injury. However, there are still conflicting results on their role in axon regeneration and therefore a lack of a cohesive mechanism on how these molecules can be targeted to promote axon repair. One major reason may be the lack of a clear definition of axon regeneration in the first place. Nevertheless, recent data from genetic studies in mice indicate that the roles of these molecules in CNS axon repair may be more intricate than previously envisioned.
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