Maternal Metabolomic Profile and Fetal Programming of Offspring Adiposity: Identification of Potentially Protective Lipid Metabolites.
Maternal Metabolomic Profile and Fetal Programming of Offspring Adiposity: Identification of Potentially Protective Lipid Metabolites.
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DOI：
10.1002/mnfr.201700889
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发表时间：
2019-01
影响因子：
5.2
通讯作者：
Entringer S
中科院分区：
文献类型：
--
作者：
Hellmuth C;Lindsay KL;Uhl O;Buss C;Wadhwa PD;Koletzko B;Entringer S
胎儿编程范式假设，肥胖的起源可以部分追溯到生命的宫内时期。然而，胎儿程序化的机制还不是很清楚，很少有研究测量新生儿时期的后代肥胖症。这项研究的目的是确定与新生儿肥胖症相关的母体代谢物及其决定因素。我们应用靶向代谢组学方法分析了从加州大学欧文分校一项前瞻性研究中收集的253名孕妇在怀孕期间收集的血浆样本。对N=121例新生儿进行了全身双X射线骨密度仪(DXA)身体成分成像。针对潜在的混杂因素和多重检验对统计模型进行了调整。我们确定了六种烷基连接的磷脂酰胆碱(PCAE)，含有20：4的脂肪酸，与新生儿体脂百分比显著负相关。表明较高的社会经济地位、非西班牙裔种族和较高的非酯化脂肪酸百分比的因素与这些PCEA呈正相关。PCae中所含的多不饱和脂肪酸20：4可能会对未来的肥胖倾向产生有益的影响。孕前和早孕因素是这些PCAE的决定因素，强调了解决怀孕前条件对新生儿肥胖症进行胎儿规划的重要性。
The fetal programming paradigm posits that the origins of obesity can be traced, in part, to the intrauterine period of life. However, the mechanisms underlying fetal programming are not well understood, and few studies have measured offspring adiposity in the neonatal period. The aim of this study was to identify maternal metabolites, and their determinants, that are associated with neonatal adiposity. We applied a targeted metabolomics approach to analyze plasma samples collected across gestation from a well-characterized cohort of 253 pregnant women participating in a prospective study at the University of California, Irvine. Whole-body Dual X-Ray Absorptiometry (DXA) imaging of body composition was obtained in N=121 newborns. Statistical models were adjusted for potential confounders and multiple testing. We identified six alkyl-linked phosphatidylcholines (PCae), containing fatty acid 20:4, that were significantly and negatively associated with neonatal body fat percentage. Factors indicating higher socioeconomic status, non-Hispanic ethnicity and higher non-esterified fatty acid percentages were positively associated with these PCae. The polyunsaturated fatty acid 20:4 contained in PCae may exert a beneficial effect with respect to future propensity for obesity development. Pre- and early-pregnancy factors are determinants of these PCae, highlighting the importance of addressing pre-conceptional conditions for fetal programming of newborn adiposity.
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影响因子：
7.1
作者：
Muhlhausler, Beverly S.;Yelland, Lisa N.;Makrides, Maria
通讯作者：
Makrides, Maria
影响因子：
3.7
作者：
Lindsay KL;Hellmuth C;Uhl O;Buss C;Wadhwa PD;Koletzko B;Entringer S
通讯作者：
Entringer S
影响因子：
3.2
作者：
Breij, Laura M.;Steegers-Theunissen, Regine P. M.;Hokken-Koelega, Anita C. S.
通讯作者：
Hokken-Koelega, Anita C. S.
DOI：
10.1017/s204017441500001x
发表时间：
2015-04
影响因子：
1.7
作者：
Hivert MF;Perng W;Watkins SM;Newgard CS;Kenny LC;Kristal BS;Patti ME;Isganaitis E;DeMeo DL;Oken E;Gillman MW
通讯作者：
Gillman MW
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y