Evaluating and Comparing Behavioural and Electrophysiological Estimates of Neural Health in Cochlear Implant Users.
Evaluating and Comparing Behavioural and Electrophysiological Estimates of Neural Health in Cochlear Implant Users.
复制标题
评估和比较行为和电生理估计的神经健康的植入用户。
DOI：
10.1007/s10162-020-00773-0
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Carlyon RP
中科院分区：
文献类型：
--
作者：
Brochier T;Guérit F;Deeks JM;Garcia C;Bance M;Carlyon RP
沿耳蜗的神经健康变化可以降低由人工耳蜗（CIs）传递的声音的频谱和时间表征。我们评估并比较了一种电生理测量和两种行为测量，这两种测量已被提议作为神经健康模式的估计，以探索不同测量提供收敛和一致的神经健康估计的程度。所有测量数据均来自Cochlear Corporation CI的相同11名用户。两种行为测量是多脉冲整合（MPI）和极性效应（PE），都是在每个受试者的七个电极上测量的。MPI被测量为80 pps和1000 pps阈值之间的差异，PE被测量为80 pps阴极中心和阳极中心四相（QP）脉冲序列之间的阈值差异。有人提出，良好的神经健康与大的MPI和大的负PE（阴极脉冲比阳极脉冲的阈值低）相对应。电生理指标为间期间隙（IPG）对ECAP振幅生长函数（AGF）偏移量的影响，该偏移量与豚鼠螺旋神经节神经元密度相关。这种“IPG偏移”是在用于行为测量的相同电极子集上获得的。尽管测试-重测信度很高，但无论是通过电极阵列的受试者内比较，还是受试者之间的平均值比较，神经健康估计之间都没有显著的相关性。然后使用螺旋神经节神经元群体的现象学模型来研究可能构成不同神经健康估计的生理机制。结合实验和建模结果，证明了PE、MPI和IPG偏移量可能反映了电极-神经界面的不同特征。
Variations in neural health along the cochlea can degrade the spectral and temporal representation of sounds conveyed by cochlear implants (CIs). We evaluated and compared one electrophysiological measure and two behavioural measures that have been proposed as estimates of neural health patterns, in order to explore the extent to which the different measures provide converging and consistent neural health estimates. All measures were obtained from the same 11 users of the Cochlear Corporation CI. The two behavioural measures were multipulse integration (MPI) and the polarity effect (PE), both measured on each of seven electrodes per subject. MPI was measured as the difference between thresholds at 80 pps and 1000 pps, and PE as the difference in thresholds between cathodic- and anodic-centred quadraphasic (QP) 80-pps pulse trains. It has been proposed that good neural health corresponds to a large MPI and to a large negative PE (lower thresholds for cathodic than anodic pulses). The electrophysiological measure was the effect of interphase gap (IPG) on the offset of the ECAP amplitude growth function (AGF), which has been correlated with spiral ganglion neuron density in guinea pigs. This ‘IPG offset’ was obtained on the same subset of electrodes used for the behavioural measures. Despite high test–retest reliability, there were no significant correlations between the neural health estimates for either within-subject comparisons across the electrode array, or between-subject comparisons of the means. A phenomenological model of a population of spiral ganglion neurons was then used to investigate physiological mechanisms that might underlie the different neural health estimates. The combined experimental and modelling results provide evidence that PE, MPI and IPG offset may reflect different characteristics of the electrode-neural interface.
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影响因子：
2.8
作者：
Hughes, Michelle L.;Baudhuin, Jacquelyn L.;Goehring, Jenny L.
通讯作者：
Goehring, Jenny L.
影响因子：
2.4
作者：
Carlyon, Robert P.;Deeks, John M.;Macherey, Olivier
通讯作者：
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DOI：
10.1007/s10162-009-0194-7
发表时间：
2010-06-01
影响因子：
2.4
作者：
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通讯作者：
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影响因子：
2.8
作者：
COLOMBO, J;PARKINS, CW
通讯作者：
PARKINS, CW
影响因子：
3.7
作者：
Buchman, Craig A.;Roush, Patricia A.;Grose, John H.
通讯作者：
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