Associations between specific sleep and circadian characteristics and alcohol use disorder criteria and problems.
Associations between specific sleep and circadian characteristics and alcohol use disorder criteria and problems.
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DOI：
10.1016/j.addbeh.2022.107348
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发表时间：
2022-09
影响因子：
4.4
通讯作者：
Pedersen, Sarah L.
中科院分区：
文献类型：
--
作者：
Boness, Cassandra L.;Hasler, Brant P.;Sheehan, Haley;Pedersen, Sarah L.
关键词：
鉴于酒精使用障碍(AUD)的显著异质性，以及对AUD个体特征的了解日益优先，进行AUD的症状水平检查是重要的。睡眠和昼夜节律紊乱已经显示出与饮酒和AUD的强烈关联，但很少有研究在症状或问题层面检查这些关联，迄今为止的研究集中在一两个睡眠/昼夜节律特征上。我们试图调查(A)特定的AUD症状和(B)酒精相关问题的领域，以及在自然环境中每天收集的多种睡眠特征之间的联系。从社区招募年轻的成年饮酒者(N=159，MAGE=23.9，58.5%女性，6.3%亚裔，35.9%黑人或非裔美国人，51.6%白人，5.0%多种族)，并完成基线访问和长达18天的自然主义评估。除了饮酒外，一些睡眠/昼夜节律特征，包括夜间、较晚的中段睡眠时间和较短的总睡眠时间，一直与危险使用症状有关。夜晚(Beta[SE]=0.21[0.00]，p<；.01)是角色干扰的酒精相关问题领域的显著预测因子。探索性分析没有发现睡眠/昼夜节律特征与大麻相关问题之间的显著联系。睡眠/昼夜节律特征与AUD及相关问题之间的关系可能是由一组较窄的症状驱动的，例如危险使用和角色干扰。这可能是由于奖赏处理或认知控制等领域的共同机械功能障碍造成的。因此，这些与酒精相关的症状和问题可以通过针对这些潜在机制的跨诊断治疗方法来解决。
Given the significant heterogeneity of alcohol use disorder (AUD) and the increasing priority to understand individual profiles of AUD, pursuing symptom-level examinations of AUD is important. Disturbances in sleep and circadian rhythms have demonstrated robust associations with alcohol consumption and AUD, yet little research has examined these associations at the symptom- or problem-levels and research to date has focused on one or two sleep/circadian characteristics. We sought to investigate the associations between (a) specific AUD symptoms and (b) domains of alcohol-related problems, and multiple sleep characteristics, collected at a daily level in the naturalistic environment. Young adult drinkers were recruited from the community (N=159, Mage=23.9, 58.5% female, 6.3% Asian, 35.9% Black or African American, 51.6% White, 5.0% multiracial) and completed a baseline visit as well as up to 18 days of naturalistic assessment. Several sleep/circadian characteristics, including eveningness, later midsleep timing, and shorter total sleep time, were consistently associated with the hazardous use symptom, above and beyond alcohol consumption. Eveningness (beta[SE]=0.21[0.00], p <.01) was a significant predictor of the alcohol-related problem domain of role interference. Exploratory analyses did not find significant associations between sleep/circadian characteristics and cannabis-related problems. The relationship between sleep/circadian characteristics and AUD and related problems may be driven by a narrower set of symptoms, such as hazardous use and role interference. This may be due to shared mechanistic dysfunction in domains such as reward processing or cognitive control. Thus, these alcohol-related symptoms and problems may be addressed through transdiagnostic treatment approaches that target these underlying mechanisms.
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