Citrobacter rodentium infection at the gut-brain axis interface.

Citrobacter rodentium infection at the gut-brain axis interface.
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DOI:
10.1016/j.mib.2021.06.003
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发表时间:
2021-10
影响因子:
5.4
通讯作者:
Cuesta S
Cuesta S
中科院分区:
生物学2区
文献类型:
--
作者:
Martins FH;Cuesta S

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肠-脑轴在维持胃肠道内稳态中起着关键作用。几种肠道病原体已经开发出了感知神经化学分子以调节其在肠道中的毒力的策略。此外,越来越多的证据表明,肠道生态失调会强烈影响宿主的大脑反应。在这里,我们回顾了不同的机制,已经提出了调解肠-脑轴通信使用啮齿类柠檬酸杆菌,一种天然的小鼠肠道病原体和最广泛使用的小动物模型之一,用于研究宿主-微生物相互作用。我们强调已经确定了C.啮齿类动物在定植期间感知宿主神经化学物质以及受肠道病原体定植影响的行为反应和脑病理。
The gut-brain axis plays a critical role in the maintenance of the gastrointestinal tract homeostasis. Several enteric pathogens have developed strategies to sense neurochemical molecules to regulate their virulence in the gut. Additionally, there is growing evidence that gut dysbiosis can strongly affect host brain responses. Here we review different mechanisms that have been proposed to mediate gut-brain axis communication using Citrobacter rodentium, a natural murine enteric pathogen and one of the most widely used small animal models for studying host-microbe interactions. We highlight studies that have identified specific pathways used by C. rodentium to sense host neurochemicals during colonization as well as behavioral responses and brain pathologies affected by pathogen colonization of the gut.
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发表时间: 2022-05
影响因子: 3.4
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